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@ARTICLE{Mooshage:298355,
      author       = {C. M. Mooshage and D. Tsilingiris and L. Schimpfle and T.
                      Fleming and S. Herzig and J. Szendroedi and S. Heiland and
                      M. Bendszus and S. Kopf and F. Kurz$^*$ and J. Jende$^*$ and
                      Z. Kender},
      title        = {{I}ntradermal {A}dvanced {G}lycation {E}nd-products
                      {R}elate to {R}educed {S}ciatic {N}erve {S}tructural
                      {I}ntegrity in {T}ype 2 {D}iabetes.},
      journal      = {Clinical neuroradiology},
      volume       = {35},
      number       = {2},
      issn         = {1869-1439},
      address      = {München},
      publisher    = {Urban $\&$ Vogel},
      reportid     = {DKFZ-2025-00256},
      pages        = {385-394},
      year         = {2025},
      note         = {2025 Jun;35(2):385-394},
      abstract     = {Cardiovascular risk management is beneficial, but stringent
                      glycemic control does not prevent the progression of distal
                      sensorimotor polyneuropathy (DSPN). Persistent
                      hyperglycemia-induced alterations and cardiovascular factors
                      may contribute to diabetes-associated nerve damage. This
                      study aimed to evaluate the correlation between skin
                      auto-fluorescence (sAF), an indicator of dermal advanced
                      glycation end-product (AGE) accumulations, cardiovascular
                      risk, and changes in peripheral nerve integrity.Sixty-two
                      individuals with type 2 diabetes (T2D) (20 women and 42
                      men), including 29 diagnosed with DSPN (7 women and 22 men),
                      and 10 healthy controls (HC) underwent diffusion tensor MR
                      imaging of the sciatic nerve to assess fractional anisotropy
                      (FA), an indicator of nerve structural integrity. sAF
                      measurements were combined with clinical, serological, and
                      electrophysiological evaluations. Arterial stiffness was
                      assessed via pulse wave velocity (PWV).sAF (HC 2.1 ± 0.25
                      AU, nDSPN 2.3 ± 0.47, DSPN 2.6 ± 0.43; p = 0.005) was
                      higher in individuals with DSPN compared to HC (p = 0.010)
                      and individuals without DSPN (p = 0.035). Within the group
                      of T2D FA correlated negatively with sAF (r = -0.49, p <
                      0.001), PWV (r = -0.40, p = 0.009) and high-sensitivity
                      troponin T (hsTNT), a marker of microvascular damage (r =
                      -0.39, p < 0.001). In DSPN, sAF correlated positively with
                      hsTNT (r = 0.58, p = 0.005) and with PWV (r = 0.52, p =
                      0.007), the sciatic nerve's FA correlated negatively with
                      PWV (r = -0.47, p = 0.010).This study is the first to show
                      close correlations between reduced peripheral nerve
                      integrity and both intradermal AGE deposition and arterial
                      stiffness in individuals with T2D. These findings highlight
                      a mechanistic link between glycation-related vascular injury
                      and neuronal damage emphasizing the importance of
                      cardiovascular risk management in preventing DSPN.},
      keywords     = {Advanced glycation end products (Other) / Diabetic
                      neuropathy (Other) / Diffusion tensor imaging (Other) /
                      Distal symmetric polyneuropathy (Other) / Magnetic resonance
                      neurography (Other) / Skin autofluorescence (Other)},
      cin          = {E010},
      cid          = {I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39880998},
      doi          = {10.1007/s00062-024-01493-1},
      url          = {https://inrepo02.dkfz.de/record/298355},
}