%0 Journal Article
%A Calderón, Eduardo
%A Kiefer, Lena S
%A Schmidt, Fabian P
%A Lan, Wenhong
%A Brendlin, Andreas S
%A Reinert, Christian P
%A Singer, Stephan
%A Reischl, Gerald
%A Hinterleitner, Martina
%A Dittmann, Helmut
%A la Fougère, Christian
%A Trautwein, Nils F
%T One-day dual-tracer examination in neuroendocrine neoplasms: a real advantage of low activity LAFOV PET imaging.
%J European journal of nuclear medicine and molecular imaging
%V 52
%N 7
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DKFZ-2025-00262
%P 2463-2476
%D 2025
%Z 2025 Jun;52(7):2463-2476
%X Somatostatin receptor (SSTR)-PET is crucial for effective treatment stratification of neuroendocrine neoplasms (NENs). In highly proliferating or poorly differentiated NENs, dual-tracer approaches using additional [18F]FDG PET can effectively identify SSTR-negative disease, usually requiring separate imaging sessions. We evaluated the feasibility of a one-day dual-tracer imaging protocol with a low activity [18F]FDG PET followed by an SSTR-PET using the recently introduced [18F]SiFAlin-TATE tracer in a long axial field-of-view (LAFOV) PET/CT scanner and its implications in patient management.Twenty NEN patients were included in this study. Initially, a low activity [18F]FDG PET was performed (0.5 ± 0.01 MBq/kg; PET scan 60 min p.i.). After 4.2 ± 0.09 h after completion of the [18F]FDG PET, a standard activity of [18F]SiFAlin-TATE was administered (3.0 MBq/kg; PET scan 90 min p.i.). To ensure the quantification accuracy of the second scan, we evaluated the potential impact of residual [18F]FDG activity by segmenting organs with minimal physiological SSTR-tracer uptake, such as the brain and myocardium, and assessing the activity concentrations (ACTs) of tumor lesions. Residual tumor lesion ACTs of [18F]FDG were calculated by factoring fluorine-18 decay, identifying a maximum residual ACT of 15
%K Dual-tracer PET (Other)
%K LAFOV PET/CT (Other)
%K Low activity [18F]FDG PET (Other)
%K Neuroendocrine neoplasms (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39883139
%R 10.1007/s00259-025-07073-w
%U https://inrepo02.dkfz.de/record/298364