%0 Journal Article
%A Papadimitriou, Nikos
%A Kazmi, Nabila
%A Tsilidis, Konstantinos K
%A Richmond, Rebecca C
%A Lynch, Brigid M
%A Bendinelli, Benedetta
%A Ricceri, Fulvio
%A Sánchez, Maria-Jose
%A Trobajo-Sanmartín, Camino
%A Jakszyn, Paula
%A Simeon, Vittorio
%A Severi, Gianluca
%A Perduca, Vittorio
%A Truong, Therese
%A Ferrari, Pietro
%A Keski-Rahkonen, Pekka
%A Weiderpass, Elisabete
%A Eichelmann, Fabian
%A Schulze, Matthias B
%A Katzke, Verena
%A Turzanski-Fortner, Renée
%A Heath, Alicia K
%A Aune, Dagfinn
%A Harewood, Rhea
%A Dahm, Christina C
%A Llorente, Adrian
%A Gunter, Marc J
%A Murphy, Neil
%A Lewis, Sarah J
%T Identifying metabolomic mediators of the physical activity and colorectal cancer relationship.
%J Cancer epidemiology, biomarkers & prevention
%V 34
%N 4
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2025-00263
%P 578-587
%D 2025
%Z 2025 Apr 3;34(4):578-587
%X Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer (CRC). However, the mediating role of the circulating metabolome in this relationship remains unclear.Targeted metabolomics data from 6,055 participants in the EPIC cohort were used to identify metabolites associated with PA and derive a metabolomic signature of PA levels. PA levels were estimated using the validated Cambridge PA index based on baseline questionnaires. Mediation analyses were conducted in a nested case-control study (1,585 cases, 1,585 controls) to examine whether individual metabolites and the metabolomic signature mediated the PA-CRC association.PA was inversely associated with CRC risk (odds ratio [OR] per category change: 0.90, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39883068
%R 10.1158/1055-9965.EPI-24-1390
%U https://inrepo02.dkfz.de/record/298365