TY  - JOUR
AU  - Papadimitriou, Nikos
AU  - Kazmi, Nabila
AU  - Tsilidis, Konstantinos K
AU  - Richmond, Rebecca C
AU  - Lynch, Brigid M
AU  - Bendinelli, Benedetta
AU  - Ricceri, Fulvio
AU  - Sánchez, Maria-Jose
AU  - Trobajo-Sanmartín, Camino
AU  - Jakszyn, Paula
AU  - Simeon, Vittorio
AU  - Severi, Gianluca
AU  - Perduca, Vittorio
AU  - Truong, Therese
AU  - Ferrari, Pietro
AU  - Keski-Rahkonen, Pekka
AU  - Weiderpass, Elisabete
AU  - Eichelmann, Fabian
AU  - Schulze, Matthias B
AU  - Katzke, Verena
AU  - Turzanski-Fortner, Renée
AU  - Heath, Alicia K
AU  - Aune, Dagfinn
AU  - Harewood, Rhea
AU  - Dahm, Christina C
AU  - Llorente, Adrian
AU  - Gunter, Marc J
AU  - Murphy, Neil
AU  - Lewis, Sarah J
TI  - Identifying metabolomic mediators of the physical activity and colorectal cancer relationship.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 34
IS  - 4
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2025-00263
SP  - 578-587
PY  - 2025
N1  - 2025 Apr 3;34(4):578-587
AB  - Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer (CRC). However, the mediating role of the circulating metabolome in this relationship remains unclear.Targeted metabolomics data from 6,055 participants in the EPIC cohort were used to identify metabolites associated with PA and derive a metabolomic signature of PA levels. PA levels were estimated using the validated Cambridge PA index based on baseline questionnaires. Mediation analyses were conducted in a nested case-control study (1,585 cases, 1,585 controls) to examine whether individual metabolites and the metabolomic signature mediated the PA-CRC association.PA was inversely associated with CRC risk (odds ratio [OR] per category change: 0.90, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:39883068
DO  - DOI:10.1158/1055-9965.EPI-24-1390
UR  - https://inrepo02.dkfz.de/record/298365
ER  -