000298413 001__ 298413
000298413 005__ 20251002115233.0
000298413 0247_ $$2doi$$a10.1038/s41467-025-56547-w
000298413 0247_ $$2pmid$$apmid:39893177
000298413 0247_ $$2pmc$$apmc:PMC11787355
000298413 0247_ $$2altmetric$$aaltmetric:173743458
000298413 037__ $$aDKFZ-2025-00269
000298413 041__ $$aEnglish
000298413 082__ $$a500
000298413 1001_ $$0P:(DE-He78)bc4a5e69aaad6fee8ca94e2f1d60b443$$aChih, Yu-Chan$$b0$$eFirst author$$udkfz
000298413 245__ $$aVaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen.
000298413 260__ $$a[London]$$bSpringer Nature$$c2025
000298413 3367_ $$2DRIVER$$aarticle
000298413 3367_ $$2DataCite$$aOutput Types/Journal article
000298413 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1740748910_28237
000298413 3367_ $$2BibTeX$$aARTICLE
000298413 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000298413 3367_ $$00$$2EndNote$$aJournal Article
000298413 500__ $$a#EA:D170#LA:D170# / DKFZ-ZMBH-Alliance / HI-TRON
000298413 520__ $$aT cell receptor-engineered T cells (TCR-T) could be advantageous in glioblastoma by allowing safe and ubiquitous targeting of the glioblastoma-derived peptidome. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1), is a clinically targetable glioblastoma antigen associated with glioblastoma cell stemness. Here, we identify a therapeutic HLA-A*02-restricted PTPRZ1-reactive TCR retrieved from a vaccinated glioblastoma patient. Single-cell sequencing of primary brain tumors shows PTPRZ1 overexpression in malignant cells, especially in glioblastoma stem cells (GSCs) and astrocyte-like cells. The validated vaccine-induced TCR recognizes the endogenously processed antigen without off-target cross-reactivity. PTPRZ1-specific TCR-T (PTPRZ1-TCR-T) kill target cells antigen-specifically, and in murine experimental brain tumors, their combined intravenous and intracerebroventricular administration is efficacious. PTPRZ1-TCR-T maintain stem cell memory phenotype in vitro and in vivo and lyse all examined HLA-A*02+ primary glioblastoma cell lines with a preference for GSCs and astrocyte-like cells. In summary, we demonstrate the proof of principle to employ TCR-T to treat glioblastoma.
000298413 536__ $$0G:(DE-HGF)POF4-314$$a314 - Immunologie und Krebs (POF4-314)$$cPOF4-314$$fPOF IV$$x0
000298413 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000298413 650_7 $$2NLM Chemicals$$aReceptors, Antigen, T-Cell
000298413 650_7 $$2NLM Chemicals$$aCancer Vaccines
000298413 650_7 $$0EC 3.1.3.48$$2NLM Chemicals$$aPTPRZ1 protein, human
000298413 650_7 $$2NLM Chemicals$$aHLA-A2 Antigen
000298413 650_7 $$0EC 3.1.3.48$$2NLM Chemicals$$aReceptor-Like Protein Tyrosine Phosphatases, Class 5
000298413 650_7 $$2NLM Chemicals$$aHLA-A*02 antigen
000298413 650_7 $$2NLM Chemicals$$aAntigens, Neoplasm
000298413 650_2 $$2MeSH$$aGlioblastoma: therapy
000298413 650_2 $$2MeSH$$aGlioblastoma: immunology
000298413 650_2 $$2MeSH$$aHumans
000298413 650_2 $$2MeSH$$aAnimals
000298413 650_2 $$2MeSH$$aReceptors, Antigen, T-Cell: immunology
000298413 650_2 $$2MeSH$$aReceptors, Antigen, T-Cell: metabolism
000298413 650_2 $$2MeSH$$aBrain Neoplasms: immunology
000298413 650_2 $$2MeSH$$aBrain Neoplasms: therapy
000298413 650_2 $$2MeSH$$aMice
000298413 650_2 $$2MeSH$$aNeoplastic Stem Cells: immunology
000298413 650_2 $$2MeSH$$aNeoplastic Stem Cells: metabolism
000298413 650_2 $$2MeSH$$aCell Line, Tumor
000298413 650_2 $$2MeSH$$aCancer Vaccines: immunology
000298413 650_2 $$2MeSH$$aHLA-A2 Antigen: immunology
000298413 650_2 $$2MeSH$$aHLA-A2 Antigen: metabolism
000298413 650_2 $$2MeSH$$aHLA-A2 Antigen: genetics
000298413 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000298413 650_2 $$2MeSH$$aT-Lymphocytes: metabolism
000298413 650_2 $$2MeSH$$aImmunotherapy, Adoptive: methods
000298413 650_2 $$2MeSH$$aReceptor-Like Protein Tyrosine Phosphatases, Class 5: metabolism
000298413 650_2 $$2MeSH$$aReceptor-Like Protein Tyrosine Phosphatases, Class 5: genetics
000298413 650_2 $$2MeSH$$aAntigens, Neoplasm: immunology
000298413 650_2 $$2MeSH$$aAntigens, Neoplasm: metabolism
000298413 650_2 $$2MeSH$$aFemale
000298413 7001_ $$0P:(DE-He78)4e4283ceae29ad813e03619bb0eadbd4$$aDietsch, Amelie C$$b1$$udkfz
000298413 7001_ $$0P:(DE-He78)970a7a41bdad66b1c4f5529fce171fcd$$aKoopmann, Philipp$$b2$$udkfz
000298413 7001_ $$0P:(DE-He78)88de8ba75b18dd92d742eb7eab04a1b3$$aMa, Xiujian$$b3
000298413 7001_ $$0P:(DE-He78)661f199a31f6d53b12f3c348103dc4e4$$aAgardy, Dennis Alexander$$b4$$udkfz
000298413 7001_ $$0P:(DE-He78)4f736f168f0ce95be559de11103aef72$$aZhao, Binghao$$b5$$udkfz
000298413 7001_ $$0P:(DE-He78)3735edce41649376fec34cf8b3a1843d$$aDe Roia, Alice$$b6$$udkfz
000298413 7001_ $$0P:(DE-He78)6b3b1cf7d9ae5f0e2b6a7d2fbb10fe8e$$aKourtesakis, Alexandros$$b7$$udkfz
000298413 7001_ $$0P:(DE-He78)bed62b0b74cf1048663fbefeb4b5d7bc$$aKilian, Michael$$b8$$udkfz
000298413 7001_ $$0P:(DE-He78)afffcfd84a16cb161571e823086e4fa8$$aKrämer, Christopher$$b9$$udkfz
000298413 7001_ $$0P:(DE-He78)c77fccff3e6c42b017b2e8a09813590c$$aSuwala, Abigail K$$b10$$udkfz
000298413 7001_ $$aStenzinger, Miriam$$b11
000298413 7001_ $$aBoenig, Halvard$$b12
000298413 7001_ $$aBlum, Agnieszka$$b13
000298413 7001_ $$aPienkowski, Victor Murcia$$b14
000298413 7001_ $$0P:(DE-He78)ee15545d88dc3d1e68f3bcda451f0b51$$aAman, Kuralay$$b15$$udkfz
000298413 7001_ $$0P:(DE-He78)45aa4fa7b16296bd3454cc3b68c33fc1$$aBecker, Jonas$$b16$$udkfz
000298413 7001_ $$0P:(DE-He78)23651302d01bf4c56448eceb8143e482$$aFeldmann, Henrike$$b17$$udkfz
000298413 7001_ $$0P:(DE-He78)e681100c540b628a2bdbd48772b4fb50$$aBunse, Theresa$$b18$$udkfz
000298413 7001_ $$0P:(DE-He78)15dff5647002b4dcfe892b251cd14b62$$aHarbottle, Richard$$b19$$udkfz
000298413 7001_ $$0P:(DE-He78)3743a1b712edca2ffa829b7096d7037e$$aRiemer, Angelika$$b20$$udkfz
000298413 7001_ $$0P:(DE-He78)76aeb2431f7458c9261e69c5420390c6$$aLiu, Haikun$$b21$$udkfz
000298413 7001_ $$aEtminan, Nima$$b22
000298413 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b23$$udkfz
000298413 7001_ $$0P:(DE-He78)ce9cbc0fcc94b04884d88105f812ed01$$aRatliff, Miriam$$b24$$udkfz
000298413 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b25$$udkfz
000298413 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b26$$udkfz
000298413 7001_ $$0P:(DE-He78)9b97ca569bcb00dfda69382bc7261700$$aGreen, Edward$$b27$$udkfz
000298413 7001_ $$0P:(DE-He78)e579130c57e8c686ed1c2dedfa595985$$aBunse, Lukas$$b28$$eLast author$$udkfz
000298413 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-56547-w$$gVol. 16, no. 1, p. 1262$$n1$$p1262$$tNature Communications$$v16$$x2041-1723$$y2025
000298413 8767_ $$8SN-2025-00449-b$$92025-05-26$$d2025-10-01$$eAPC$$jZahlung erfolgt
000298413 909CO $$ooai:inrepo02.dkfz.de:298413$$pVDB$$pOpenAPC$$popenCost
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bc4a5e69aaad6fee8ca94e2f1d60b443$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4e4283ceae29ad813e03619bb0eadbd4$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)970a7a41bdad66b1c4f5529fce171fcd$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)88de8ba75b18dd92d742eb7eab04a1b3$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)661f199a31f6d53b12f3c348103dc4e4$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4f736f168f0ce95be559de11103aef72$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3735edce41649376fec34cf8b3a1843d$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b3b1cf7d9ae5f0e2b6a7d2fbb10fe8e$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)bed62b0b74cf1048663fbefeb4b5d7bc$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)afffcfd84a16cb161571e823086e4fa8$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c77fccff3e6c42b017b2e8a09813590c$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ee15545d88dc3d1e68f3bcda451f0b51$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)45aa4fa7b16296bd3454cc3b68c33fc1$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)23651302d01bf4c56448eceb8143e482$$aDeutsches Krebsforschungszentrum$$b17$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e681100c540b628a2bdbd48772b4fb50$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)15dff5647002b4dcfe892b251cd14b62$$aDeutsches Krebsforschungszentrum$$b19$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3743a1b712edca2ffa829b7096d7037e$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)76aeb2431f7458c9261e69c5420390c6$$aDeutsches Krebsforschungszentrum$$b21$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aDeutsches Krebsforschungszentrum$$b23$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ce9cbc0fcc94b04884d88105f812ed01$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aDeutsches Krebsforschungszentrum$$b25$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aDeutsches Krebsforschungszentrum$$b26$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9b97ca569bcb00dfda69382bc7261700$$aDeutsches Krebsforschungszentrum$$b27$$kDKFZ
000298413 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e579130c57e8c686ed1c2dedfa595985$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000298413 9131_ $$0G:(DE-HGF)POF4-314$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImmunologie und Krebs$$x0
000298413 9141_ $$y2025
000298413 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-01-30T07:48:07Z
000298413 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-01-30T07:48:07Z
000298413 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2024-01-30T07:48:07Z
000298413 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2024-01-30T07:48:07Z
000298413 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-01-02
000298413 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-01-02
000298413 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000298413 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000298413 915pc $$0PC:(DE-HGF)0002$$2APC$$aDFG OA Publikationskosten
000298413 915pc $$0PC:(DE-HGF)0003$$2APC$$aDOAJ Journal
000298413 9202_ $$0I:(DE-He78)D170-20160331$$kD170$$lKKE Neuroimmunologie und Hirntumorimmunologie$$x0
000298413 9201_ $$0I:(DE-He78)D170-20160331$$kD170$$lKKE Neuroimmunologie und Hirntumorimmunologie$$x0
000298413 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000298413 9201_ $$0I:(DE-He78)A240-20160331$$kA240$$lA240 Molekulare Neurogenetik$$x2
000298413 9201_ $$0I:(DE-He78)D420-20160331$$kD420$$lDNA-Vektoren$$x3
000298413 9201_ $$0I:(DE-He78)B320-20160331$$kB320$$lKKE Neuroonkologie$$x4
000298413 9201_ $$0I:(DE-He78)B300-20160331$$kB300$$lKKE Neuropathologie$$x5
000298413 9201_ $$0I:(DE-He78)D410-20160331$$kD410$$lImmuntherapie und -prävention$$x6
000298413 9200_ $$0I:(DE-He78)D170-20160331$$kD170$$lKKE Neuroimmunologie und Hirntumorimmunologie$$x0
000298413 980__ $$ajournal
000298413 980__ $$aVDB
000298413 980__ $$aI:(DE-He78)D170-20160331
000298413 980__ $$aI:(DE-He78)HD01-20160331
000298413 980__ $$aI:(DE-He78)A240-20160331
000298413 980__ $$aI:(DE-He78)D420-20160331
000298413 980__ $$aI:(DE-He78)B320-20160331
000298413 980__ $$aI:(DE-He78)B300-20160331
000298413 980__ $$aI:(DE-He78)D410-20160331
000298413 980__ $$aUNRESTRICTED
000298413 980__ $$aAPC