%0 Journal Article
%A Fu, Ruojin
%A Chen, Xuechen
%A Seum, Teresa
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Alcohol consumption, polygenic risk score and the risk of colorectal neoplasia.
%J JNCI cancer spectrum
%V 9
%N 2
%@ 2515-5091
%C Oxford
%I Oxford University Press
%M DKFZ-2025-00282
%P pkaf017
%D 2025
%Z #EA:C070#LA:C070# / 2025 Mar 3;9(2):pkaf017
%X Excess alcohol consumption is associated with increased risk of colorectal cancer (CRC), but the evidence on the individual and joint effects of alcohol consumption and genetic risk on the occurrence of various stages of colorectal carcinogenesis is limited.We evaluated the associations of alcohol consumption and a polygenic risk score (PRS) based on 140 CRC-related loci with findings of colorectal neoplasia among 4,662 participants in the German screening colonoscopy program. Analyses were conducted by multiple logistic regression. We determined genetic risk equivalents (GREs) to quantify the effect of alcohol consumption in terms of the difference in PRS conveying equivalent risk.Moderate and high (12-<25 and ≥25 g/day) alcohol consumption was associated with increased risk of advanced colorectal neoplasia (aOR [95
%K alcohol consumption (Other)
%K colorectal neoplasia (Other)
%K genetic risk equivalent (Other)
%K polygenic risk score (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39898811
%R 10.1093/jncics/pkaf017
%U https://inrepo02.dkfz.de/record/298557