TY  - JOUR
AU  - Fu, Ruojin
AU  - Chen, Xuechen
AU  - Seum, Teresa
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Alcohol consumption, polygenic risk score and the risk of colorectal neoplasia.
JO  - JNCI cancer spectrum
VL  - 9
IS  - 2
SN  - 2515-5091
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2025-00282
SP  - pkaf017
PY  - 2025
N1  - #EA:C070#LA:C070# / 2025 Mar 3;9(2):pkaf017
AB  - Excess alcohol consumption is associated with increased risk of colorectal cancer (CRC), but the evidence on the individual and joint effects of alcohol consumption and genetic risk on the occurrence of various stages of colorectal carcinogenesis is limited.We evaluated the associations of alcohol consumption and a polygenic risk score (PRS) based on 140 CRC-related loci with findings of colorectal neoplasia among 4,662 participants in the German screening colonoscopy program. Analyses were conducted by multiple logistic regression. We determined genetic risk equivalents (GREs) to quantify the effect of alcohol consumption in terms of the difference in PRS conveying equivalent risk.Moderate and high (12-<25 and ≥25 g/day) alcohol consumption was associated with increased risk of advanced colorectal neoplasia (aOR [95
KW  - alcohol consumption (Other)
KW  - colorectal neoplasia (Other)
KW  - genetic risk equivalent (Other)
KW  - polygenic risk score (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39898811
DO  - DOI:10.1093/jncics/pkaf017
UR  - https://inrepo02.dkfz.de/record/298557
ER  -