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000298560 1001_ $$00000-0001-5119-7550$$aAldape, Kenneth$$b0
000298560 245__ $$acIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics.
000298560 260__ $$aOxford$$bOxford University Press$$c2025
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000298560 520__ $$aGenome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the initial CNS tumor DNA methylation classifier in 2018, this platform has been increasingly used as a diagnostic tool for CNS tumors, with multiple studies showing the value and utility of DNA methylation-based classification of CNS tumors. A Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) Working Group was therefore convened to describe the current state of the field and to provide advice based on lessons learned to date. Here, we provide recommendations for the use of DNA methylation-based classification in CNS tumor diagnostics, emphasizing the attributes and limitations of the modality. We emphasize that the methylation classifier is one diagnostic tool to be used alongside previously established diagnostic tools in a fully integrated fashion. In addition, we provide examples of the inclusion of DNA methylation data within the layered diagnostic reporting format endorsed by the World Health Organization (WHO) and the International Collaboration on Cancer Reporting. We emphasize the need for backward compatibility of future platforms to enable accumulated data to be compatible with new versions of the array. Finally, we outline the specific connections between methylation classes and CNS WHO tumor types to aid in the interpretation of classifier results. It is hoped that this update will assist the neuro-oncology community in the interpretation of DNA methylation classifier results to facilitate the accurate diagnosis of CNS tumors and thereby help guide patient management.
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000298560 650_7 $$2Other$$aCNS tumors
000298560 650_7 $$2Other$$aDNA methylation profiling
000298560 650_7 $$2Other$$amolecular classification
000298560 650_7 $$2Other$$aneuropathology
000298560 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b1$$udkfz
000298560 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b2$$udkfz
000298560 7001_ $$00000-0003-2757-6782$$aGiannini, Caterina$$b3
000298560 7001_ $$00000-0001-8935-1744$$aGilbert, Mark R$$b4
000298560 7001_ $$00000-0003-2618-4402$$aHawkins, Cynthia$$b5
000298560 7001_ $$00000-0002-9884-1240$$aHench, Jürgen$$b6
000298560 7001_ $$00000-0002-7833-2158$$aJacques, Thomas S$$b7
000298560 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b8$$udkfz
000298560 7001_ $$aLouis, David N$$b9
000298560 7001_ $$aMueller, Sabine$$b10
000298560 7001_ $$00000-0003-0997-4728$$aOrr, Brent A$$b11
000298560 7001_ $$00000-0003-4861-0898$$aNasrallah, MacLean$$b12
000298560 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b13$$udkfz
000298560 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b14$$udkfz
000298560 7001_ $$00000-0003-0752-0917$$aSnuderl, Matija$$b15
000298560 7001_ $$aSolomon, David$$b16
000298560 7001_ $$00000-0002-8164-1517$$aVarlet, Pascale$$b17
000298560 7001_ $$aWesseling, Pieter$$b18
000298560 773__ $$0PERI:(DE-600)3009682-0$$a10.1093/noajnl/vdae228$$gVol. 7, no. 1, p. vdae228$$n1$$pvdae228$$tNeuro-oncology advances$$v7$$x2632-2498$$y2025
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