TY  - JOUR
AU  - Aldape, Kenneth
AU  - Capper, David
AU  - von Deimling, Andreas
AU  - Giannini, Caterina
AU  - Gilbert, Mark R
AU  - Hawkins, Cynthia
AU  - Hench, Jürgen
AU  - Jacques, Thomas S
AU  - Jones, David
AU  - Louis, David N
AU  - Mueller, Sabine
AU  - Orr, Brent A
AU  - Nasrallah, MacLean
AU  - Pfister, Stefan
AU  - Sahm, Felix
AU  - Snuderl, Matija
AU  - Solomon, David
AU  - Varlet, Pascale
AU  - Wesseling, Pieter
TI  - cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics.
JO  - Neuro-oncology advances
VL  - 7
IS  - 1
SN  - 2632-2498
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2025-00285
SP  - vdae228
PY  - 2025
AB  - Genome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the initial CNS tumor DNA methylation classifier in 2018, this platform has been increasingly used as a diagnostic tool for CNS tumors, with multiple studies showing the value and utility of DNA methylation-based classification of CNS tumors. A Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) Working Group was therefore convened to describe the current state of the field and to provide advice based on lessons learned to date. Here, we provide recommendations for the use of DNA methylation-based classification in CNS tumor diagnostics, emphasizing the attributes and limitations of the modality. We emphasize that the methylation classifier is one diagnostic tool to be used alongside previously established diagnostic tools in a fully integrated fashion. In addition, we provide examples of the inclusion of DNA methylation data within the layered diagnostic reporting format endorsed by the World Health Organization (WHO) and the International Collaboration on Cancer Reporting. We emphasize the need for backward compatibility of future platforms to enable accumulated data to be compatible with new versions of the array. Finally, we outline the specific connections between methylation classes and CNS WHO tumor types to aid in the interpretation of classifier results. It is hoped that this update will assist the neuro-oncology community in the interpretation of DNA methylation classifier results to facilitate the accurate diagnosis of CNS tumors and thereby help guide patient management.
KW  - CNS tumors (Other)
KW  - DNA methylation profiling (Other)
KW  - molecular classification (Other)
KW  - neuropathology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39902391
C2  - pmc:PMC11788596
DO  - DOI:10.1093/noajnl/vdae228
UR  - https://inrepo02.dkfz.de/record/298560
ER  -