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@ARTICLE{Velz:298571,
      author       = {J. Velz and L. Freudenmann$^*$ and G. Medici and M.
                      Dubbelaar and M. Mohme and D. R. Ghasemi$^*$ and J. Scheid
                      and D. J. Kowalewski and A. B. Patterson and A. M.
                      Zeitlberger and K. Lamszus and M. Westphal and M. Eyrich and
                      M. Messing-Jünger and A. Röhrig and H. Reinhard and K.
                      Beccaria and R. B. Craveiro and B. M. Frey and M. Sill$^*$
                      and S. Nahnsen and M. Gauder and K. Kapolou and M. Silginer
                      and T. Weiss and H.-G. Wirsching and P. Roth and M. Grotzer
                      and N. Krayenbühl and O. Bozinov and L. Regli and H.-G.
                      Rammensee$^*$ and E. J. Rushing and F. Sahm$^*$ and J.
                      Walz$^*$ and M. Weller and M. C. Neidert},
      title        = {{M}apping naturally presented {T} cell antigens in
                      medulloblastoma based on integrative multi-omics.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-00288},
      pages        = {1364},
      year         = {2025},
      abstract     = {Medulloblastoma is the most frequent malignant primary
                      brain tumor in children. Despite recent advances in
                      integrated genomics, the prognosis in children with
                      high-risk medulloblastoma remains devastating, and new
                      tumor-specific therapeutic approaches are needed. Here, we
                      present an atlas of naturally presented T cell antigens in
                      medulloblastoma. We map the human leukocyte antigen
                      (HLA)-presented peptidomes of 28 tumors and perform
                      comparative immunopeptidome profiling against an in-house
                      benign database. Medulloblastoma is shown to be a rich
                      source of tumor-associated antigens, naturally presented on
                      HLA class I and II molecules. Remarkably, most
                      tumor-associated peptides and proteins are
                      subgroup-specific, whereas shared presentation among all
                      subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4)
                      is rare. Functional testing of top-ranking novel candidate
                      antigens demonstrates the induction of peptide-specific T
                      cell responses, supporting their potential for T cell
                      immunotherapy. This study is an in-depth mapping of
                      naturally presented T cell antigens in medulloblastoma.
                      Integration of immunopeptidomics, transcriptomics, and
                      epigenetic data leads to the identification of a large set
                      of actionable targets that can be further used for the
                      translation into the clinical setting by facilitating the
                      informed design of immunotherapeutic approaches to children
                      with medulloblastoma.},
      keywords     = {Medulloblastoma: immunology / Medulloblastoma: genetics /
                      Humans / Cerebellar Neoplasms: immunology / Cerebellar
                      Neoplasms: genetics / Antigens, Neoplasm: immunology /
                      Antigens, Neoplasm: genetics / Child / T-Lymphocytes:
                      immunology / Antigen Presentation: immunology /
                      Histocompatibility Antigens Class I: immunology /
                      Histocompatibility Antigens Class I: genetics / Male /
                      Female / Peptides: immunology / HLA Antigens: genetics / HLA
                      Antigens: immunology / Proteomics / Immunotherapy: methods /
                      Multiomics / Antigens, Neoplasm (NLM Chemicals) /
                      Histocompatibility Antigens Class I (NLM Chemicals) /
                      Peptides (NLM Chemicals) / HLA Antigens (NLM Chemicals)},
      cin          = {TU01 / B062 / HD01 / B300},
      ddc          = {500},
      cid          = {I:(DE-He78)TU01-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39904979},
      doi          = {10.1038/s41467-025-56268-0},
      url          = {https://inrepo02.dkfz.de/record/298571},
}