%0 Journal Article
%A Chalitsios, Christos V
%A Markozannes, Georgios
%A Papagiannopoulos, Christos
%A Aglago, Elom K
%A Berndt, Sonja I
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Cao, Yin
%A Chan, Andrew T
%A Dimou, Niki
%A Drew, David A
%A French, Amy J
%A Georgeson, Peter
%A Giannakis, Marios
%A Gruber, Stephen B
%A Gunter, Marc J
%A Harrison, Tabitha A
%A Hoffmeister, Michael
%A Hsu, Li
%A Huang, Wen-Yi
%A Hullar, Meredith Aj
%A Huyghe, Jeroen R
%A Lynch, Brigid M
%A Moreno, Victor
%A Newton, Christina C
%A Nowak, Jonathan A
%A Obón-Santacana, Mireia
%A Ogino, Shuji
%A Qu, Conghui
%A Schmit, Stephanie L
%A Steinfelder, Robert S
%A Sun, Wei
%A Thomas, Claire E
%A Toland, Amanda E
%A Trinh, Quang M
%A Ugai, Tomotaka
%A Um, Caroline Y
%A Van Guelpen, Bethany
%A Zaidi, Syed H
%A Murphy, Neil
%A Peters, Ulrike
%A Phipps, Amanda I
%A Tsilidis, Konstantinos K
%T Waist circumference, a body shape index, and molecular subtypes of colorectal cancer: A pooled analysis of four cohort studies.
%J Cancer epidemiology, biomarkers & prevention
%V 34
%N 4
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2025-00293
%P 568-577
%D 2025
%Z 2025 Apr 3;34(4):568-577
%X Background Waist circumference (WC) and its allometric counterpart, 'a body shape index' (ABSI), are risk factors for colorectal cancer (CRC); however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease. Methods Data from 2,772 CRC cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analysed individually and in combination (Jass-types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall CRC risk and in case-only analyses evaluating heterogeneity by molecular subtype, respectively. Results Higher WC (ORper 5cm=1.06, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39898780
%R 10.1158/1055-9965.EPI-24-1534
%U https://inrepo02.dkfz.de/record/298576