TY  - JOUR
AU  - Chalitsios, Christos V
AU  - Markozannes, Georgios
AU  - Papagiannopoulos, Christos
AU  - Aglago, Elom K
AU  - Berndt, Sonja I
AU  - Buchanan, Daniel D
AU  - Campbell, Peter T
AU  - Cao, Yin
AU  - Chan, Andrew T
AU  - Dimou, Niki
AU  - Drew, David A
AU  - French, Amy J
AU  - Georgeson, Peter
AU  - Giannakis, Marios
AU  - Gruber, Stephen B
AU  - Gunter, Marc J
AU  - Harrison, Tabitha A
AU  - Hoffmeister, Michael
AU  - Hsu, Li
AU  - Huang, Wen-Yi
AU  - Hullar, Meredith Aj
AU  - Huyghe, Jeroen R
AU  - Lynch, Brigid M
AU  - Moreno, Victor
AU  - Newton, Christina C
AU  - Nowak, Jonathan A
AU  - Obón-Santacana, Mireia
AU  - Ogino, Shuji
AU  - Qu, Conghui
AU  - Schmit, Stephanie L
AU  - Steinfelder, Robert S
AU  - Sun, Wei
AU  - Thomas, Claire E
AU  - Toland, Amanda E
AU  - Trinh, Quang M
AU  - Ugai, Tomotaka
AU  - Um, Caroline Y
AU  - Van Guelpen, Bethany
AU  - Zaidi, Syed H
AU  - Murphy, Neil
AU  - Peters, Ulrike
AU  - Phipps, Amanda I
AU  - Tsilidis, Konstantinos K
TI  - Waist circumference, a body shape index, and molecular subtypes of colorectal cancer: A pooled analysis of four cohort studies.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 34
IS  - 4
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2025-00293
SP  - 568-577
PY  - 2025
N1  - 2025 Apr 3;34(4):568-577
AB  - Background Waist circumference (WC) and its allometric counterpart, 'a body shape index' (ABSI), are risk factors for colorectal cancer (CRC); however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease. Methods Data from 2,772 CRC cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analysed individually and in combination (Jass-types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall CRC risk and in case-only analyses evaluating heterogeneity by molecular subtype, respectively. Results Higher WC (ORper 5cm=1.06, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:39898780
DO  - DOI:10.1158/1055-9965.EPI-24-1534
UR  - https://inrepo02.dkfz.de/record/298576
ER  -