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@ARTICLE{Chalitsios:298576,
      author       = {C. V. Chalitsios and G. Markozannes and C. Papagiannopoulos
                      and E. K. Aglago and S. I. Berndt and D. D. Buchanan and P.
                      T. Campbell and Y. Cao and A. T. Chan and N. Dimou and D. A.
                      Drew and A. J. French and P. Georgeson and M. Giannakis and
                      S. B. Gruber and M. J. Gunter and T. A. Harrison and M.
                      Hoffmeister$^*$ and L. Hsu and W.-Y. Huang and M. A. Hullar
                      and J. R. Huyghe and B. M. Lynch and V. Moreno and C. C.
                      Newton and J. A. Nowak and M. Obón-Santacana and S. Ogino
                      and C. Qu and S. L. Schmit and R. S. Steinfelder and W. Sun
                      and C. E. Thomas and A. E. Toland and Q. M. Trinh and T.
                      Ugai and C. Y. Um and B. Van Guelpen and S. H. Zaidi and N.
                      Murphy and U. Peters and A. I. Phipps and K. K. Tsilidis},
      title        = {{W}aist circumference, a body shape index, and molecular
                      subtypes of colorectal cancer: {A} pooled analysis of four
                      cohort studies.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {34},
      number       = {4},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2025-00293},
      pages        = {568-577},
      year         = {2025},
      note         = {2025 Apr 3;34(4):568-577},
      abstract     = {Background Waist circumference (WC) and its allometric
                      counterpart, 'a body shape index' (ABSI), are risk factors
                      for colorectal cancer (CRC); however, it is uncertain
                      whether associations with these body measurements are
                      limited to specific molecular subtypes of the disease.
                      Methods Data from 2,772 CRC cases and 3,521 controls were
                      pooled from four cohort studies within the Genetics and
                      Epidemiology of Colorectal Cancer Consortium. Four molecular
                      markers (BRAF mutation, KRAS mutation, CpG island methylator
                      phenotype, and microsatellite instability) were analysed
                      individually and in combination (Jass-types). Multivariable
                      logistic and multinomial logistic models were used to assess
                      the associations of WC and ABSI with overall CRC risk and in
                      case-only analyses evaluating heterogeneity by molecular
                      subtype, respectively. Results Higher WC (ORper 5cm=1.06,
                      $95\%CI:1.04-1.09)$ and ABSI (ORper 1-SD=1.07,
                      $95\%CI:1.00-1.14)$ were associated with elevated CRC risk.
                      There was no evidence of heterogeneity between the molecular
                      subtypes. No difference was observed regarding the influence
                      of WC and ABSI on the four major molecular markers in
                      proximal colon, distal colon, and rectal cancer, as well as
                      in early and later onset CRC. Associations did not differ in
                      the Jass-type analysis. Conclusions Higher WC and ABSI were
                      associated with elevated CRC risk; however, they do not
                      differentially influence all four major molecular mutations
                      involved in colorectal carcinogenesis but underscore the
                      importance of maintaining a healthy body weight in CRC
                      prevention. Impact The proposed results have potential
                      utility in colorectal cancer prevention.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39898780},
      doi          = {10.1158/1055-9965.EPI-24-1534},
      url          = {https://inrepo02.dkfz.de/record/298576},
}