TY  - JOUR
AU  - Trautwein, Nils F
AU  - Calderón, Eduardo
AU  - Linder, Pia M
AU  - Reischl, Gerald
AU  - Driessen, Philippe
AU  - Lan, Wenhong
AU  - Brendlin, Andreas S
AU  - Groß, Thorben
AU  - Dittmann, Helmut
AU  - Hinterleitner, Martina
AU  - la Fougère, Christian
AU  - Schmidt, Fabian P
AU  - Kiefer, Lena S
TI  - Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner.
JO  - EJNMMI Physics
VL  - 12
IS  - 1
SN  - 2197-7364
CY  - Heidelberg
PB  - SpringerOpen
M1  - DKFZ-2025-00297
SP  - 13
PY  - 2025
AB  - 18F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to 68Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities of [18F]SiTATE on image quality, lesion detectability and quantitative PET parameters in a long axial field-of-view (LAFOV) PET/CT scanner.Twenty-four patients with histologically confirmed neuroendocrine tumor, who underwent clinically indicated [18F]SiTATE PET/CT examination (3.0 MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision Quadra LAFOV PET/CT, were included retrospectively in this study. PET list-mode data were rebinned for shorter frame durations to simulate 5 min scans with lower activities of injected radiotracer. A comparison of image reconstruction in high sensitivity (HS) and ultra-high sensitivity mode (UHS) mode was performed. Subjective image quality, noise and lesion detectability of n = 122 lesions were rated using a 5-point Likert scale. The molecular tumor volume (MTV), signal-to-noise ratio (SNR), tumor-to-liver activity concentration ratio (TLR) and standardized uptake values (SUV) were analyzed.Subjective image quality decreased with simulated reduction of injected activity with generally superior ratings in the UHS mode compared to the HS mode. Despite a reduction to 1 MBq/kg of [18F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70
KW  - LAFOV PET/CT (Other)
KW  - Low-activity [18F]SiTATE PET (Other)
KW  - Total-Body-PET (Other)
KW  - [18F]-SSTR imaging (Other)
KW  - [18F]SiTATE (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39907960
DO  - DOI:10.1186/s40658-025-00720-z
UR  - https://inrepo02.dkfz.de/record/298580
ER  -