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@ARTICLE{Trautwein:298580,
      author       = {N. F. Trautwein and E. Calderón and P. M. Linder and G.
                      Reischl and P. Driessen and W. Lan and A. S. Brendlin and T.
                      Groß and H. Dittmann and M. Hinterleitner and C. la
                      Fougère$^*$ and F. P. Schmidt and L. S. Kiefer},
      title        = {{L}ow-activity [18{F}]-somatostatin receptor ({SSTR})
                      imaging using [18{F}]{S}i{TATE} on a long axial
                      field-of-view {PET}/{CT} scanner.},
      journal      = {EJNMMI Physics},
      volume       = {12},
      number       = {1},
      issn         = {2197-7364},
      address      = {Heidelberg},
      publisher    = {SpringerOpen},
      reportid     = {DKFZ-2025-00297},
      pages        = {13},
      year         = {2025},
      abstract     = {18F-labelled somatostatin receptor tracers have recently
                      gained popularity due to their better spatial resolution,
                      longer half-life and lower costs compared to 68Ga-labeled
                      tracers. The aim of this study was to evaluate the impact
                      and limitations of reduced administered activities of
                      [18F]SiTATE on image quality, lesion detectability and
                      quantitative PET parameters in a long axial field-of-view
                      (LAFOV) PET/CT scanner.Twenty-four patients with
                      histologically confirmed neuroendocrine tumor, who underwent
                      clinically indicated [18F]SiTATE PET/CT examination (3.0
                      MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision
                      Quadra LAFOV PET/CT, were included retrospectively in this
                      study. PET list-mode data were rebinned for shorter frame
                      durations to simulate 5 min scans with lower activities of
                      injected radiotracer. A comparison of image reconstruction
                      in high sensitivity (HS) and ultra-high sensitivity mode
                      (UHS) mode was performed. Subjective image quality, noise
                      and lesion detectability of n = 122 lesions were rated using
                      a 5-point Likert scale. The molecular tumor volume (MTV),
                      signal-to-noise ratio (SNR), tumor-to-liver activity
                      concentration ratio (TLR) and standardized uptake values
                      (SUV) were analyzed.Subjective image quality decreased with
                      simulated reduction of injected activity with generally
                      superior ratings in the UHS mode compared to the HS mode.
                      Despite a reduction to 1 MBq/kg of [18F]SiTATE all lesions
                      were still detected while at 0.25 MBq/kg lesion
                      detectability decreased to $70\%$ (HS) and $93\%$ (UHS).
                      Only minor changes in SUVmean and TLR were detected with
                      reduced activity. However, reduced activities led to an
                      increase in SUVSD, which in turn caused a decrease in SNR
                      (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase
                      in deviation of the MTV.Reducing the administered activity
                      of injected [18F]SiTATE by $66\%$ to 1 MBq/kg (HS $\&$ UHS)
                      is feasible in a LAFOV PET/CT scanner, maintaining
                      clinically diagnostic image quality without statistically
                      significant deviations in PET uptake parameters and MTV.
                      Furthermore, in low activity [18F]SiTATE PET/CT, the UHS
                      mode improves image quality and noise as well as lesion
                      detectability compared to HS mode, further reinforcing the
                      clinical benefits of this recently introduced reconstruction
                      mode.},
      keywords     = {LAFOV PET/CT (Other) / Low-activity [18F]SiTATE PET (Other)
                      / Total-Body-PET (Other) / [18F]-SSTR imaging (Other) /
                      [18F]SiTATE (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39907960},
      doi          = {10.1186/s40658-025-00720-z},
      url          = {https://inrepo02.dkfz.de/record/298580},
}