%0 Journal Article
%A Moraitis, Alexandros
%A Kahl, Theresa
%A Kandziora, Jens
%A Jentzen, Walter
%A Kersting, David
%A Püllen, Lukas
%A Reis, Henning
%A Köllermann, Jens
%A Kesch, Claudia
%A Krafft, Ulrich
%A Hadaschik, Boris A
%A Zaidi, Habib
%A Herrmann, Ken
%A Barbato, Francesco
%A Fendler, Wolfgang P
%A Darr, Christopher
%A Fragoso Costa, Pedro
%T Evaluation of Surgical Margins with Intraoperative PSMA PET/CT and Their Prognostic Value in Radical Prostatectomy.
%J Journal of nuclear medicine
%V 66
%N 3
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2025-00307
%P 352-358
%D 2025
%Z 2025 Mar 3;66(3):352-358
%X Detection of positive resection margins in surgical procedures of high-risk prostate cancer is key for minimizing the risk of recurrence. This study aimed at evaluating the accuracy of functional tumor-volume segmentation in intraoperative ex vivo PET/CT for margin assessment in prostate cancer patients undergoing radical prostatectomy. Methods: Seven high-risk prostate cancer patients received [18F]PSMA-1007 before radical prostatectomy. After removal of the prostate gland, ex vivo imaging on the AURA 10 PET/CT system was performed, and functional tumor volume was segmented using 4 semiautomatic segmentation methods. Resection margins and volumes were compared with histopathology. Additionally, a supportive phantom study was conducted to assess segmentation accuracy at low radiopharmaceutical activity. Results: Clinically, 18 lesions were analyzed in intraoperative PET/CT. Sensitivity, specificity, and positive and negative predictive values of margin detection were 83
%K PET/CT (Other)
%K margin assessment (Other)
%K prostate cancer (Other)
%K radical prostatectomy (Other)
%K radioguided surgery (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39915125
%R 10.2967/jnumed.124.268719
%U https://inrepo02.dkfz.de/record/298597