TY  - JOUR
AU  - Moraitis, Alexandros
AU  - Kahl, Theresa
AU  - Kandziora, Jens
AU  - Jentzen, Walter
AU  - Kersting, David
AU  - Püllen, Lukas
AU  - Reis, Henning
AU  - Köllermann, Jens
AU  - Kesch, Claudia
AU  - Krafft, Ulrich
AU  - Hadaschik, Boris A
AU  - Zaidi, Habib
AU  - Herrmann, Ken
AU  - Barbato, Francesco
AU  - Fendler, Wolfgang P
AU  - Darr, Christopher
AU  - Fragoso Costa, Pedro
TI  - Evaluation of Surgical Margins with Intraoperative PSMA PET/CT and Their Prognostic Value in Radical Prostatectomy.
JO  - Journal of nuclear medicine
VL  - 66
IS  - 3
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2025-00307
SP  - 352-358
PY  - 2025
N1  - 2025 Mar 3;66(3):352-358
AB  - Detection of positive resection margins in surgical procedures of high-risk prostate cancer is key for minimizing the risk of recurrence. This study aimed at evaluating the accuracy of functional tumor-volume segmentation in intraoperative ex vivo PET/CT for margin assessment in prostate cancer patients undergoing radical prostatectomy. Methods: Seven high-risk prostate cancer patients received [18F]PSMA-1007 before radical prostatectomy. After removal of the prostate gland, ex vivo imaging on the AURA 10 PET/CT system was performed, and functional tumor volume was segmented using 4 semiautomatic segmentation methods. Resection margins and volumes were compared with histopathology. Additionally, a supportive phantom study was conducted to assess segmentation accuracy at low radiopharmaceutical activity. Results: Clinically, 18 lesions were analyzed in intraoperative PET/CT. Sensitivity, specificity, and positive and negative predictive values of margin detection were 83
KW  - PET/CT (Other)
KW  - margin assessment (Other)
KW  - prostate cancer (Other)
KW  - radical prostatectomy (Other)
KW  - radioguided surgery (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39915125
DO  - DOI:10.2967/jnumed.124.268719
UR  - https://inrepo02.dkfz.de/record/298597
ER  -