TY  - JOUR
AU  - Guberina, Maja
AU  - Stuschke, Martin
AU  - Flühs, Dirk
AU  - Jabbarli, Leyla
AU  - Kiefer, Tobias
AU  - Biewald, Eva
AU  - Rating, Philipp
AU  - Manke, Henning
AU  - Dalbah, Sami
AU  - Hoffmann, Christian
AU  - Guberina, Nika
AU  - Pöttgen, Christoph
AU  - Fiorentzis, Miltiadis
AU  - Foerster, Andreas
AU  - Grunewald, Tobias
AU  - Bornfeld, Norbert
AU  - Sauerwein, Wolfgang
AU  - Bechrakis, Nikolaos
AU  - Sokolenko, Ekaterina
TI  - Dose response relation for optic nerve atrophy at low-dose rate brachytherapy of uveal melanoma.
JO  - Radiotherapy and oncology
VL  - 205
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-00310
SP  - 110775
PY  - 2025
N1  - Volume 205, April 2025, 110775
AB  - Dose-response relationships for optic neuropathy and optic nerve atrophy after brachytherapy for posterior uveal melanoma were poorly defined from previous studies. Here, the outcome differences were analyzed in dependence on dosimetric factors, the applicator type, and tumor dependent variables.Primary objective was to evaluate the association of applied dose and on-set of optic nerve atrophy after brachytherapy for posterior uveal melanoma in order to allow risk estimation for new patients.This retrospective study was performed at a single high volume centre for ocular oncology. Patients receiving brachytherapy with Ruthenium-106 applicators for posterior uveal melanoma with a maximum distance between optic nerve and the nearest tumor margin of 4 optical disc diameters and follow-up with fundus photographs were included. The dose distribution at the optic nerve was reconstructed from the fundus photographs at latest follow-up and the dose-distribution of the applicator using a dedicated software. A first mask with important structural elements such as optic nerve, macula, tumor and vessels was first superimposed on the fundus photograph and adapted to the real contours. In a second step, an applicator contour mask was adapted to the radiation scar in order to calculate the dose distribution in all structures. Dose-response relations were obtained by weighted logistic regression.The maximum dose at the optic disc (ODmax) in this group of 109 patients ranged from 5.8 Gy - 242.2 Gy, median 48.7 Gy. Optic nerve atrophy was observed in 29patients. Median time to optic radiation induced optic nerve atrophy was 18 months. Using weighted logistic regression, the dependence of optic nerve atrophy on ODmax was significant (p = 0.0001, chi2 test). There was a considerable interobserver variability in ODmax values (p < 0.02, signed rank test). An additional factor influencing the dose-response was the applicator type (p = 0.0315, chi2 test). The ODmax for a probability of optic nerve atrophy of 50 
KW  - Dose response relation (Other)
KW  - Low-dose rate brachytherapy (Other)
KW  - Malignant eye tumor (Other)
KW  - Optic nerve atrophy (Other)
KW  - Optic neuropathy (Other)
KW  - Optimizing treatment (Other)
KW  - Outcome (Other)
KW  - Radiation (Other)
KW  - Uveal Melanoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39922315
DO  - DOI:10.1016/j.radonc.2025.110775
UR  - https://inrepo02.dkfz.de/record/298610
ER  -