TY  - JOUR
AU  - Li, Keva
AU  - Chadha, Manjeet
AU  - Moshier, Erin
AU  - Rosenstein, Barry S
TI  - Age-stratified analysis of health-related quality of life in patients with early-stage breast cancer receiving adjuvant radiation therapy and endocrine therapy.
JO  - Journal of geriatric oncology
VL  - 16
IS  - 2
SN  - 1879-4068
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-00314
SP  - 102195
PY  - 2025
AB  - Health-related quality of life (HRQoL) in older patients with breast cancer (BC) (≥70 years) is not well studied. This study assesses aging-related differences in patient-reported outcomes among estrogen receptor-positive (ER+) patients with BC treated with breast conservation surgery (BCS), radiation therapy (RT), and endocrine therapy (ET).Among the 2,057 patients with ER+ early-stage BC enrolled in the prospective multicenter REQUITE study, 1,003 patients receiving adjuvant RT + ET as the only systemic therapy constitute our study population. Patients were stratified by age into younger (<70 years, n = 810 patients) and older (≥70 years, n = 193 patients) groups. Prospectively collected HRQoL was measured using the validated European Organization for Research and Treatment of Cancer (EORTC) quality of life of cancer patients (QLQ-30) and breast cancer-specific quality of life (QLQ-BR23), and Multidimensional Fatigue Inventory (MFI-20) measures at baseline following BCS and pre-adjuvant treatment, post-RT, and at one-year, two-year, and three-year intervals. Statistical analysis involved a mixed model analysis of variance, weighted by propensity scoring.Older patients had a higher burden of comorbidities, larger tumor size, and higher rates of N1 disease compared to the younger group. RT boost to the lumpectomy site was more often delivered in younger participants (72 
KW  - Early-stage breast cancer, estrogen receptor positive (Other)
KW  - Endocrine therapy (Other)
KW  - Health-related quality of life (Other)
KW  - Lumpectomy (Other)
KW  - Older women (Other)
KW  - Patient-reported outcomes (Other)
KW  - Radiation therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39919652
DO  - DOI:10.1016/j.jgo.2025.102195
UR  - https://inrepo02.dkfz.de/record/298614
ER  -