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@ARTICLE{LangeDrenth:298622,
      author       = {L. Lange-Drenth and H. Willemer and M. Banse$^*$ and A.
                      Ernst$^*$ and A. Daubmann and A. Holz and C. Bleich and S.
                      Weg-Remers$^*$ and H. Schulz},
      title        = {{D}evelopment and effectiveness evaluation of an
                      interactive e-learning environment to enhance digital health
                      literacy in cancer patients: study protocol for a randomized
                      controlled trial.},
      journal      = {Frontiers in digital health},
      volume       = {7},
      issn         = {2673-253X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2025-00322},
      pages        = {1455143},
      year         = {2025},
      note         = {#LA:M100#},
      abstract     = {The Internet allows cancer patients to access information
                      about their disease at any time. However, the quality of
                      online information varies widely and is often inaccurate or
                      does not provide all the details patients need to make
                      informed decisions. Additionally, patients' often limited
                      ability to find and evaluate cancer-related online
                      information can lead to misinformation.An interactive
                      e-learning environment to promote digital health literacy
                      will be developed and evaluated for effectiveness.Cancer
                      patients who use the e-learning environment (IG1.1-IG1.3) or
                      the content of the environment as a non-interactive PDF file
                      (IG2) will show greater improvement in their digital health
                      literacy from baseline to 8 weeks after baseline compared to
                      patients who receive no such intervention, but are referred
                      to a standard information brochure.The hypothesis will be
                      tested in a stratified randomized controlled superiority
                      trial with five parallel groups and the primary endpoint of
                      digital health literacy. In an e-learning environment,
                      patients will learn strategies to use when searching for
                      reliable cancer-related online information. During
                      development, a prototype will be refined through focus
                      groups and tested for usability by experts and patients. 660
                      cancer patients will be recruited using convenience sampling
                      and randomly assigned in a 3:1:1 ratio to IG1.1-IG1.3 (three
                      variants of the environment), IG2, or the control group. Two
                      thirds of the 660 participants will be recruited through the
                      German Cancer Information Service (CIS) and one third
                      through non-CIS routes. Allocation will follow stratified
                      randomization, accounting for recruitment route (CIS vs.
                      non-CIS) and cancer type (breast cancer vs. other cancers),
                      with variable block length. The primary outcome, digital
                      health literacy, will be measured at baseline, 2 weeks, and
                      8 weeks after baseline.If the results support the primary
                      hypothesis, then the e-learning environment could empower
                      patients to retrieve more reliable information about their
                      disease. Concerns about the generalizability of the results,
                      since a disproportionate number of inquiries to the CIS come
                      from breast cancer patients, are addressed by a
                      proportionally stratified randomization strategy and
                      diversified recruitment routes.},
      keywords     = {digital health (Other) / digital health literacy (Other) /
                      e-learning (Other) / eHealth (Other) / eHealth literacy
                      (Other) / health information (Other) / health literacy
                      (Other) / medical education (Other)},
      cin          = {M100},
      ddc          = {610},
      cid          = {I:(DE-He78)M100-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39925640},
      pmc          = {pmc:PMC11802532},
      doi          = {10.3389/fdgth.2025.1455143},
      url          = {https://inrepo02.dkfz.de/record/298622},
}