%0 Journal Article
%A Braun, Lukas M.
%A Giesler, Sophie
%A Andrieux, Geoffroy
%A Riemer, Roxane
%A Talvard-Balland, Nana
%A Duquesne, Sandra
%A Rückert, Tamina
%A Unger, Susanne
%A Kreutmair, Stefanie
%A Zwick, Melissa
%A Follo, Marie
%A Hartmann, Alina
%A Osswald, Natascha
%A Melchinger, Wolfgang
%A Chapman, Stefanie
%A Hutchinson, James A.
%A Haferkamp, Sebastian
%A Torster, Leopold
%A Kött, Julian
%A Gebhardt, Christoffer
%A Hellwig, Dirk
%A Karantzelis, Nikolaos
%A Wallrabenstein, Till
%A Lowinus, Theresa
%A Yücel, Mehtap
%A Brehm, Niklas
%A Rawluk, Justyna
%A Pfeifer, Dietmar
%A Bronsert, Peter
%A Rogg, Manuel
%A Mattern, Sven
%A Heikenwälder, Mathias
%A Fusco, Stefano
%A Malek, Nisar P.
%A Singer, Stephan
%A Schmitt-Graeff, Annette
%A Ceteci, Fatih
%A Greten, Florian R.
%A Blazar, Bruce R.
%A Börries, Melanie
%A Köhler, Natalie
%A Duyster, Justus
%A Ihorst, Gabriele
%A Lassmann, Silke
%A Keye, Philip
%A Minguet, Susana
%A Schadendorf, Dirk
%A Ugurel, Selma
%A Rafei-Shamsabadi, David
%A Thimme, Robert
%A Hasselblatt, Peter
%A Bengsch, Bertram
%A Schell, Christoph
%A Pearce, Erika L.
%A Meiss, Frank
%A Becher, Burkhard
%A Funke-Lorenz, Carolin
%A Placke, Jan-Malte
%A Apostolova, Petya
%A Zeiser, Robert
%T Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity
%J Cancer cell
%V 43
%N 2
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2025-00336
%P 269 - 291.e19
%D 2025
%X Immune-related adverse events (irAEs) in cancer patients receiving immune checkpoint inhibitors (ICIs) cause morbidity and necessitate cessation of treatment. Comparing irAE treatments, we find that anti-tumor immunity is preserved in mice after extracorporeal photopheresis (ECP) but reduced with glucocorticosteroids, TNFα blockade, and α4β7-integrin inhibition. Local adiponectin production elicits a tissue-specific effect by reducing pro-inflammatory T cell frequencies in the colon while sparing tumor-specific T cell development. A prospective phase-1b/2 trial (EudraCT-No.2021-002073-26) with 14 patients reveals low ECP-related toxicity. Overall response rate for all irAEs is 92
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39933899
%R 10.1016/j.ccell.2025.01.004
%U https://inrepo02.dkfz.de/record/298893