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@ARTICLE{Braun:298893,
      author       = {L. M. Braun and S. Giesler and G. Andrieux and R. Riemer
                      and N. Talvard-Balland and S. Duquesne and T. Rückert and
                      S. Unger and S. Kreutmair and M. Zwick and M. Follo and A.
                      Hartmann and N. Osswald and W. Melchinger and S. Chapman and
                      J. A. Hutchinson and S. Haferkamp and L. Torster and J.
                      Kött and C. Gebhardt and D. Hellwig and N. Karantzelis and
                      T. Wallrabenstein and T. Lowinus and M. Yücel and N. Brehm
                      and J. Rawluk and D. Pfeifer and P. Bronsert and M. Rogg and
                      S. Mattern and M. Heikenwälder$^*$ and S. Fusco and N. P.
                      Malek and S. Singer and A. Schmitt-Graeff and F. Ceteci and
                      F. R. Greten and B. R. Blazar and M. Börries$^*$ and N.
                      Köhler and J. Duyster$^*$ and G. Ihorst and S. Lassmann and
                      P. Keye and S. Minguet and D. Schadendorf$^*$ and S.
                      Ugurel$^*$ and D. Rafei-Shamsabadi and R. Thimme and P.
                      Hasselblatt and B. Bengsch$^*$ and C. Schell and E. L.
                      Pearce and F. Meiss and B. Becher and C. Funke-Lorenz$^*$
                      and J.-M. Placke$^*$ and P. Apostolova$^*$ and R.
                      Zeiser$^*$},
      title        = {{A}diponectin reduces immune checkpoint inhibitor-induced
                      inflammation without blocking anti-tumor immunity},
      journal      = {Cancer cell},
      volume       = {43},
      number       = {2},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-00336},
      pages        = {269 - 291.e19},
      year         = {2025},
      abstract     = {Immune-related adverse events (irAEs) in cancer patients
                      receiving immune checkpoint inhibitors (ICIs) cause
                      morbidity and necessitate cessation of treatment. Comparing
                      irAE treatments, we find that anti-tumor immunity is
                      preserved in mice after extracorporeal photopheresis (ECP)
                      but reduced with glucocorticosteroids, TNFα blockade, and
                      α4β7-integrin inhibition. Local adiponectin production
                      elicits a tissue-specific effect by reducing
                      pro-inflammatory T cell frequencies in the colon while
                      sparing tumor-specific T cell development. A prospective
                      phase-1b/2 trial (EudraCT-No.2021-002073-26) with 14
                      patients reveals low ECP-related toxicity. Overall response
                      rate for all irAEs is $92\%$ $(95\%$ confidence interval
                      [CI]: $63.97\%–99.81\%);$ colitis-specific complete
                      remission rate is $100\%$ $(95\%$ CI: $63.06\%–100\%).$
                      Glucocorticosteroid dosages could be reduced for all
                      patients after ECP therapy. The ECP-adiponectin axis reduces
                      intestinal tissue-resident memory T cell activation and
                      CD4+IFN-γ+ T cells in patients with ICI-induced colitis
                      without evidence of loss of anti-tumor immunity. In
                      conclusion, we identify adiponectin as an immunomodulatory
                      molecule that controls ICI-induced irAEs without blocking
                      anti-tumor immunity.},
      cin          = {D440 / FR01 / ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)D440-20160331 / I:(DE-He78)FR01-20160331 /
                      I:(DE-He78)ED01-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39933899},
      doi          = {10.1016/j.ccell.2025.01.004},
      url          = {https://inrepo02.dkfz.de/record/298893},
}