%0 Journal Article
%A Wasilewski, David
%A Eitner, Chiara
%A Ates, Rober
%A Murad, Selin
%A Shaked, Zoe
%A Steinle, Julia Alexandra
%A Wetzel-Yalelis, Andreas
%A Sargut, Tarik Alp
%A Rösler, Judith
%A Samman, Majd Abdulhamid
%A Truckenmüller, Peter
%A Mertens, Robert
%A Kroneberg, Daniel
%A Kowski, Alexander
%A Radbruch, Helena
%A Capper, David
%A Ehret, Felix
%A Roohani, Siyer
%A Frost, Nikolaj
%A Nawabi, Jawed
%A Onken, Julia
%A Schlaak, Maximilian
%A Blohmer, Jens-Uwe
%A Pelzer, Uwe
%A Keller, Ulrich
%A Sehouli, Jalid
%A Vajkoczy, Peter
%A Keilholz, Ulrich
%A Misch, Martin
%T Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry.
%J Journal of neuro-oncology
%V nn
%@ 0167-594X
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M DKFZ-2025-00339
%P nn
%D 2025
%Z epub
%X Leptomeningeal disease (LMD) involves disseminating cancer cells to the leptomeninges and cerebrospinal fluid. The impact of intracranial parenchymal brain metastases and extracranial disease burden at LMD diagnosis remains unclear. This study evaluates these factors alongside local and systemic therapies before and after LMD diagnosis.A retrospective analysis was conducted on 188 patients diagnosed with LMD between 2011 and 2024. Data on demographics, imaging findings, and treatments were collected. Kaplan-Meier estimates were used for survival analysis, and independent prognostic factors were identified using a backward-stepwise Cox regression model.Primary cancers included breast cancer (34.0
%K Brain metastasis (Other)
%K Breast cancer (Other)
%K Lung cancer (Other)
%K Melanoma (Other)
%K Radiotherapy (Other)
%K Re-resection (Other)
%K Resection (Other)
%K Survival (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39932528
%R 10.1007/s11060-025-04937-x
%U https://inrepo02.dkfz.de/record/298896