TY  - JOUR
AU  - Wasilewski, David
AU  - Eitner, Chiara
AU  - Ates, Rober
AU  - Murad, Selin
AU  - Shaked, Zoe
AU  - Steinle, Julia Alexandra
AU  - Wetzel-Yalelis, Andreas
AU  - Sargut, Tarik Alp
AU  - Rösler, Judith
AU  - Samman, Majd Abdulhamid
AU  - Truckenmüller, Peter
AU  - Mertens, Robert
AU  - Kroneberg, Daniel
AU  - Kowski, Alexander
AU  - Radbruch, Helena
AU  - Capper, David
AU  - Ehret, Felix
AU  - Roohani, Siyer
AU  - Frost, Nikolaj
AU  - Nawabi, Jawed
AU  - Onken, Julia
AU  - Schlaak, Maximilian
AU  - Blohmer, Jens-Uwe
AU  - Pelzer, Uwe
AU  - Keller, Ulrich
AU  - Sehouli, Jalid
AU  - Vajkoczy, Peter
AU  - Keilholz, Ulrich
AU  - Misch, Martin
TI  - Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry.
JO  - Journal of neuro-oncology
VL  - nn
SN  - 0167-594X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DKFZ-2025-00339
SP  - nn
PY  - 2025
N1  - epub
AB  - Leptomeningeal disease (LMD) involves disseminating cancer cells to the leptomeninges and cerebrospinal fluid. The impact of intracranial parenchymal brain metastases and extracranial disease burden at LMD diagnosis remains unclear. This study evaluates these factors alongside local and systemic therapies before and after LMD diagnosis.A retrospective analysis was conducted on 188 patients diagnosed with LMD between 2011 and 2024. Data on demographics, imaging findings, and treatments were collected. Kaplan-Meier estimates were used for survival analysis, and independent prognostic factors were identified using a backward-stepwise Cox regression model.Primary cancers included breast cancer (34.0
KW  - Brain metastasis (Other)
KW  - Breast cancer (Other)
KW  - Lung cancer (Other)
KW  - Melanoma (Other)
KW  - Radiotherapy (Other)
KW  - Re-resection (Other)
KW  - Resection (Other)
KW  - Survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39932528
DO  - DOI:10.1007/s11060-025-04937-x
UR  - https://inrepo02.dkfz.de/record/298896
ER  -