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@ARTICLE{Hartmann:298897,
      author       = {A. Hartmann and S. D. Grabitz and P. S. Wild and K. J.
                      Lackner and T. Münzel and J. G. Kerahrodi and S. Singer$^*$
                      and K. Geschke and J. M. Schattenberg and S. Konstantinides
                      and N. Pfeiffer and A. K. Schuster},
      title        = {{G}ender-specific changes in vision-related quality of life
                      over time - results from the population-based {G}utenberg
                      {H}ealth {S}tudy.},
      journal      = {Graefe's archive for clinical and experimental
                      ophthalmology},
      volume       = {263},
      number       = {7},
      issn         = {0721-8494},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-00340},
      pages        = {1825-1835},
      year         = {2025},
      note         = {2025 Jul;263(7):1825-1835},
      abstract     = {To investigate potential gender- and age-specific changes
                      over time in vision-related quality of life (VRQoL) on a
                      population-based level. Further, factors associated with
                      changes in VRQoL will be explored.The Gutenberg Health Study
                      is a population-based, prospective, observational,
                      single-center cohort study in Germany. VRQoL was quantified
                      at baseline and 5-year follow-up using the visual function
                      scale (VFS) and socio-emotional scale (SES-VRQoL). VFS and
                      SES-VRQoL are calculated using the 'National Eye Institute
                      25-Item Visual Functioning Questionnaire' (NEI-VFQ-25). Both
                      scales range from 0 to 100, 0 corresponds to the sum that
                      would be achieved if a participant had answered all items
                      with the worst performance, and 100 corresponds to the sum
                      of all items answered with the best possible performance.
                      Distance-corrected visual acuity was measured in both eyes.
                      Univariable and multivariable linear regression analyses
                      were conducted to identify ophthalmic and sociodemographic
                      predictors of VRQoL.A total of 10,152 participants (mean age
                      54.2 years; $49.2\%$ female) were included in the analysis.
                      The mean visual functioning decreased from 89.6 (IQR: 81.3,
                      95.1) at baseline to 85.9 (IQR: 79.2, 92.6) at 5-year
                      follow-up in the VFS (p < 0.001). Participants'
                      socio-emotional well-being remained the same from baseline
                      to 5-year follow-up in the SES-VRQoL. In multivariable
                      linear regression analysis, older age (0.03, p = 0.002) and
                      female gender (-1.00, p < 0.001) were associated with a VFS
                      change. Higher baseline socioeconomic status was associated
                      with a slightly positive increase in VFS (0.07, p = 0.001).
                      Deterioration of visual acuity in the better and
                      worse-seeing eye was associated with negative VFS change
                      over 5 years (better-seeing eye: -5.41, p < 0.001,
                      worse-seeing eye: -7.35, p < 0.001). Baseline socioeconomic
                      status was associated with SES-VRQoL change (0.06, p <
                      0.001). The negative change in visual acuity showed an
                      association with negative SES-VRQoL in the better (-4.15, p
                      < 0.001) and worse-seeing eye (-3.75, p < 0.001).
                      Stratification of the regression models by age and gender
                      showed greater reductions in VFS scores with visual acuity
                      changes in participants aged 65 years or older and a more
                      pronounced decrease in female participants over 5 years.This
                      study demonstrated an association between visual acuity
                      change and change in VRQoL over 5 years, with a greater
                      decrease in female participants and participants aged 65
                      years or older. The better-seeing eye and the worse-seeing
                      eye both had an impact on changes in VRQoL.What is known
                      Previous studies have predominantly used cross-sectional
                      designs to investigate the correlation between visual acuity
                      and vision-related quality of life, with limited insights
                      into how visual acuity changes over time affect
                      vision-related quality of life in a large cohort. What is
                      new This study demonstrates that visual acuity changes
                      significantly impact VRQoL over a 5-year period, with a
                      notable decrease observed in female participants and those
                      aged 65 years or older. Analysis reveals both the
                      better-seeing and worse-seeing eye contribute to changes in
                      VRQoL, highlighting the necessity of comprehensive visual
                      assessments in both eyes for a more accurate understanding
                      of VRQoL outcomes.},
      keywords     = {Gender factors (Other) / Healthy ageing (Other) / Quality
                      of life (Other) / VFQ-25 (Other) / Visual acuity (Other) /
                      Visual impairment (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39934353},
      doi          = {10.1007/s00417-025-06741-9},
      url          = {https://inrepo02.dkfz.de/record/298897},
}