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@ARTICLE{Delecluse:298902,
      author       = {S. Delecluse$^*$ and F. Harder and F. Keller and M. Zeier
                      and S. Zschäbitz},
      title        = {{O}nconephrology: {T}he {S}ignificance of {R}enal
                      {F}unction for the {D}evelopment, {D}iagnosis, and
                      {T}reatment of {C}ancer.},
      journal      = {Deutsches Ärzteblatt international},
      volume       = {121},
      number       = {24},
      issn         = {1866-0452},
      address      = {Köln},
      publisher    = {Dt. Ärzte-Verl.},
      reportid     = {DKFZ-2025-00341},
      pages        = {793-799},
      year         = {2024},
      note         = {#EA:D400# /
                      https://di.aerzteblatt.de/int/archive/article/241946},
      abstract     = {Modern treatment strategies have markedly improved the
                      chances of survival for patients with cancer. As the
                      population ages, cancer is becoming more common, as is
                      chronic kidney disease (CKD). CKD increases the risk of
                      cancer; conversely, cancer treatments can cause CKD.This
                      review is based on publications retrieved by a selective
                      literature search concerning the epidemiology and
                      comorbidities of cancer and kidney diseases, the renal side
                      effects of new anticancer drugs, and the need to consider
                      renal function in cancer treatment.The prevalence of severe
                      CKD in Germany is $2.3\%.$ Persons who have CKD, are on
                      dialysis, or have undergone kidney transplantation are 1.2
                      to 3.5 times more likely to develop cancer than the general
                      population. For patients who have CKD or are
                      dialysis-dependent, the doses of approximately $67\%$ of
                      anticancer drugs need to be adjusted on the basis of their
                      glomerular filtration rate and the renally excreted fraction
                      of the drug. The optimal efficacy of therapeutic drugs, as
                      well as of those used for diagnostic purposes, and the
                      minimization of side effects, depend critically on adapted
                      dosing and on proper timing of administration before or
                      after dialysis. Modern anticancer drugs can also cause acute
                      kidney damage (incidence with checkpoint inhibitors:
                      $2-16\%).Patients$ who have CKD, are on dialysis, or have
                      undergone kidney transplantation make up a considerable
                      fraction of persons being treated for cancer, and they need
                      interdisciplinary treatment.},
      subtyp        = {Review Article},
      keywords     = {Humans / Neoplasms: complications / Neoplasms: therapy /
                      Renal Insufficiency, Chronic: therapy / Renal Insufficiency,
                      Chronic: complications / Renal Insufficiency, Chronic:
                      diagnosis / Renal Insufficiency, Chronic: physiopathology /
                      Antineoplastic Agents: adverse effects / Germany:
                      epidemiology / Glomerular Filtration Rate / Kidney
                      Transplantation / Renal Dialysis / Prevalence /
                      Antineoplastic Agents (NLM Chemicals)},
      cin          = {D400},
      ddc          = {610},
      cid          = {I:(DE-He78)D400-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39417369},
      doi          = {10.3238/arztebl.m2024.0193},
      url          = {https://inrepo02.dkfz.de/record/298902},
}