TY  - JOUR
AU  - Jabbarli, Leyla
AU  - Fiorentzis, Miltiadis
AU  - Rating, Philipp
AU  - Schmidt, Boerge
AU  - Biewald, Eva
AU  - Guberina, Nika
AU  - Flühs, Dirk
AU  - Bornfeld, Norbert
AU  - Sauerwein, Wolfgang
AU  - Stuschke, Martin
AU  - Bechrakis, Nikolaos E
AU  - Guberina, Maja
TI  - Functional outcome after Brachytherapy with bi-nuclide (Ru-106/Iodine-125) plaques in large uveal melanomas.
JO  - Radiation oncology
VL  - 20
IS  - 1
SN  - 1748-717X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00342
SP  - 22
PY  - 2025
AB  - Preservation of visual acuity remains a challenging issue after globe sparing therapy of large uveal melanoma. The aim of our study was analyzing the functional outcome after brachytherapy with bi-nuclide plaques (BBNP), maintaining prognostic factors for legal blindness (LB).We have analyzed all consecutive patients with large uveal melanoma treated with BBNP at our institution between 01/1999 and 12/2020. The post-treatment follow-up data were screened up to 06/2023. Univariate and multivariate Cox regression analysis was performed to identify predictive factors for development of LB following BBNP.Overall, 570 patients with median age of 65.6 years (interquartile range [IQR]: 54.5-74.0) underwent BBNP. During the median post-treatment follow-up of 30.8 months (IQR: 12.9-57.3), LB was diagnosed in 287 (50.4
KW  - 106Ruthenium (Other)
KW  - 125Iodine (Other)
KW  - Bi-nuclide plaque (Other)
KW  - Brachytherapy (Other)
KW  - Uveal melanoma (Other)
KW  - Visual acuity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39940039
DO  - DOI:10.1186/s13014-024-02576-6
UR  - https://inrepo02.dkfz.de/record/298903
ER  -