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000298907 1001_ $$aPeng, Tianping$$b0
000298907 245__ $$aIndividualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy.
000298907 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2025
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000298907 520__ $$aTumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) that accurately recapitulates the cellular and molecular pathology of human brain tumors. Patient-derived tumor explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling culture of a wide range of human tumors in the central nervous system (CNS), including adult, pediatric, and metastatic brain cancers. Histopathological, genomic, epigenomic, and single-cell RNA sequencing (scRNA-seq) analyses demonstrated that the IPTO model recapitulates cellular heterogeneity and molecular features of original tumors. Crucially, we showed that the IPTO model predicts patient-specific drug responses, including resistance mechanisms, in a prospective patient cohort. Collectively, the IPTO model represents a major breakthrough in preclinical modeling of human cancers, which provides a path toward personalized cancer therapy.
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000298907 650_7 $$2Other$$abrain metastasis
000298907 650_7 $$2Other$$aglioblastoma
000298907 650_7 $$2Other$$apatient tumor organoid
000298907 650_7 $$2Other$$apredictive patient model
000298907 650_7 $$2Other$$atemozolomide
000298907 650_7 $$2Other$$atumor heterogeneity
000298907 7001_ $$0P:(DE-He78)88de8ba75b18dd92d742eb7eab04a1b3$$aMa, Xiujian$$b1$$eFirst author
000298907 7001_ $$aHua, Wei$$b2
000298907 7001_ $$0P:(DE-He78)be724b82903aa397737196d8200edb30$$aWang, Changwen$$b3
000298907 7001_ $$aChu, Youjun$$b4
000298907 7001_ $$aSun, Meng$$b5
000298907 7001_ $$aFermi, Valentina$$b6
000298907 7001_ $$0P:(DE-He78)875b52cddc351d6eca86de4f404f4631$$aHamelmann, Stefan$$b7
000298907 7001_ $$0P:(DE-He78)9c599f876c762bc78d289674c15ba4a5$$aLindner, Katharina$$b8
000298907 7001_ $$0P:(DE-He78)7e77b1ec44a0797f186de678c66f80a0$$aShao, Chunxuan$$b9
000298907 7001_ $$0P:(DE-He78)786f582fd4178a697bb48213edd8aad4$$aZaman, Julia$$b10
000298907 7001_ $$0P:(DE-He78)013c1f7493419ce6a1a10fd28abb172b$$aTian, Weili$$b11
000298907 7001_ $$0P:(DE-He78)24e61e2f659895c9e6d595647a29bf36$$aZhuo, Yue$$b12
000298907 7001_ $$0P:(DE-He78)044b8e7cc52bce80fe9afd70f8f4d44e$$aHarim, Yassin$$b13
000298907 7001_ $$0P:(DE-He78)79d514e9270d1a0c8b17992db50542f1$$aStöffler, Nadja$$b14
000298907 7001_ $$0P:(DE-He78)6268906e54e5ca1f69e966a42d92bff7$$aHammann, Linda$$b15
000298907 7001_ $$0P:(DE-He78)4ddaf0b8a060cc0da9341ecef9ce161e$$aXiao, Qungen$$b16
000298907 7001_ $$0P:(DE-He78)ec03875913cf6c00f279fe768d4d7b5d$$aJin, Xiaoliang$$b17
000298907 7001_ $$aWarta, Rolf$$b18
000298907 7001_ $$aLotsch, Catharina$$b19
000298907 7001_ $$aZhuang, Xuran$$b20
000298907 7001_ $$aFeng, Yuan$$b21
000298907 7001_ $$aFu, Minjie$$b22
000298907 7001_ $$aZhang, Xin$$b23
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000298907 7001_ $$aXu, Hao$$b25
000298907 7001_ $$aQiu, Fufang$$b26
000298907 7001_ $$aXie, Liqian$$b27
000298907 7001_ $$aZhang, Yi$$b28
000298907 7001_ $$aZhu, Wei$$b29
000298907 7001_ $$aDu, Zunguo$$b30
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000298907 7001_ $$aSchneider, Mark$$b32
000298907 7001_ $$aEichhorn, Florian$$b33
000298907 7001_ $$aLefevre, Arthur$$b34
000298907 7001_ $$0P:(DE-He78)f2efee17b6ca2f790176a2c036912536$$aPusch, Stefan$$b35
000298907 7001_ $$aGrinevich, Valery$$b36
000298907 7001_ $$0P:(DE-He78)ce9cbc0fcc94b04884d88105f812ed01$$aRatliff, Miriam$$b37
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000298907 7001_ $$aXiang, Yangfei$$b41
000298907 7001_ $$aUnterberg, Andreas$$b42
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000298907 7001_ $$0P:(DE-He78)76aeb2431f7458c9261e69c5420390c6$$aLiu, Haikun$$b47
000298907 7001_ $$aMao, Ying$$b48
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