%0 Journal Article
%A Lalos, Fotios
%A Flühs, Dirk
%A Guberina, Maja
%A Bornfeld, Norbert
%A Stuschke, Martin
%A Sauerwein, Wolfgang
%A Bechrakis, Nikolaos E
%T Tumor- and Radiation-Related Complications after Ruthenium-106 Brachytherapy in Small to Medium Uveal Melanomas (Part 1). [Tumor- und strahlenbedingte Komplikationen nach Ruthenium-106-Brachytherapie bei kleinen bis mittelgroßen Aderhautmelanomen (Teil 1)].
%J Klinische Monatsblätter für Augenheilkunde
%V 242
%N 2
%@ 0023-2165
%C Stuttgart
%I Thieme
%M DKFZ-2025-00354
%P 105 - 115
%D 2025
%X The purpose of this study was to analyze tumor-related complications after ruthenium-106 brachytherapy in patients with uveal melanoma, with respect to local tumor control, insufficient radiation response, enucleation, and metastasis rate.This retrospective study included 608 patients treated consecutively with ruthenium-106 brachytherapy between January 2008 and December 2010 at the Department of Ophthalmology, University Hospital Essen. The occurrence of radiation-induced results was analyzed by estimating the risk by applying the Kaplan-Meier method, i.e., the 'time to event' analysis. The Cox model test was used for the univariate and multivariate risk factor analyses. The median follow-up was 51 months after primary treatment.Tumor recurrence was found in 21 patients (3.5
%K Humans
%K Uveal Neoplasms: radiotherapy
%K Brachytherapy: methods
%K Brachytherapy: adverse effects
%K Melanoma: radiotherapy
%K Ruthenium Radioisotopes: therapeutic use
%K Male
%K Female
%K Middle Aged
%K Aged
%K Retrospective Studies
%K Adult
%K Radiation Injuries: etiology
%K Aged, 80 and over
%K Treatment Outcome
%K Risk Factors
%K Neoplasm Recurrence, Local: prevention & control
%K Neoplasm Recurrence, Local: radiotherapy
%K Young Adult
%K Eye Enucleation
%K Prevalence
%K Adolescent
%K Ruthenium Radioisotopes (NLM Chemicals)
%K Ruthenium-106 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38354842
%R 10.1055/a-2268-0985
%U https://inrepo02.dkfz.de/record/298918