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@ARTICLE{Klein:298924,
      author       = {L. Klein and G. Herget and H. Schmal and A.-L. Grosu$^*$
                      and T. Sprave$^*$ and R. Stoian$^*$},
      title        = {{R}adiotherapy of osseus metastases.[{S}trahlentherapie
                      ossärer {M}etastasen.]},
      journal      = {Best Practice Onkologie},
      volume       = {20},
      issn         = {0946-4565},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-00358},
      pages        = {8–17},
      year         = {2025},
      note         = {Volume 20, pages 8–17, (2025)},
      abstract     = {Background: Radiotherapy is an essential part of cancer
                      therapy in general and particularly of the treatment of bone
                      metastases. Objective: This article aims to give an overview
                      of the indications, technique, regimes, outcomes, and
                      limitations of radiotherapy for the treatment of bone
                      metastases. Materials and methods: The current literature
                      and guidelines on radiation therapy of bone metastases were
                      reviewed under the guidance of experts from the Department
                      of Radiotherapy and Orthopedics at the University Hospital
                      of Freiburg (Comprehensive Cancer Center Freiburg, CCCF).
                      Results: Radiation therapy successfully reduces pain in
                      $60\%$ of patients with bone metastases within 2–3 weeks.
                      It induces reossification within 3–6 months. In a
                      palliative setting, fractionation can be reduced to even
                      single-fraction treatments, resulting in nearly the same
                      pain reduction in symptomatic bone metastases as compared to
                      multiple-fraction treatment regimes. Stereotactic ablative
                      radiotherapy seems to have the greatest potential in the
                      treatment of oligometastatic disease. Conclusion: Radiation
                      therapy is a potent tool to treat most bone metastases—not
                      only in palliative but also in curative settings. More
                      recently developed techniques of radiotherapy have even
                      increased the therapeutic effectiveness while reducing side
                      effects in surrounding organs at risk.},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1007/s11654-024-00626-9},
      url          = {https://inrepo02.dkfz.de/record/298924},
}