000298928 001__ 298928
000298928 005__ 20250217163750.0
000298928 0247_ $$2doi$$a10.1093/jleuko/qiae250
000298928 0247_ $$2pmid$$apmid:39953806
000298928 0247_ $$2ISSN$$a0741-5400
000298928 0247_ $$2ISSN$$a1938-3673
000298928 037__ $$aDKFZ-2025-00362
000298928 041__ $$aEnglish
000298928 082__ $$a570
000298928 1001_ $$aCibir, Zülal$$b0
000298928 245__ $$aRisk beyond neutropenia: insights into neutrophil migration from newly diagnosed AML until late after allogeneic stem cell transplantation.
000298928 260__ $$aTokyo$$bOxford University Press$$c2025
000298928 3367_ $$2DRIVER$$aarticle
000298928 3367_ $$2DataCite$$aOutput Types/Journal article
000298928 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1739788801_14462
000298928 3367_ $$2BibTeX$$aARTICLE
000298928 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000298928 3367_ $$00$$2EndNote$$aJournal Article
000298928 520__ $$aQuantification of neutrophil counts is the most relevant assessment of cellular immunity in clinical practice. Patients with neutropenia are considered at risk and are categorized according to its severity. The incidence of febrile neutropenia varies, but patients with acute myeloid leukemia are traditionally considered at high risk, especially following myelotoxic treatments. To provide additional functional parameters, we investigated the ex vivo migration properties and morphology of neutrophils in 10 patients with acute myeloid leukemia using single-cell video-microscopy and discovered, in addition to neutropenia, highly pathological neutrophil migration patterns and polarization defects in patients with untreated acute myeloid leukemia. Neutrophil speed was the most sensitive parameter and significantly lower at leukemia diagnosis (9.067 vs 15.810 µm/min, P = 0.0025) compared to healthy controls (n = 46). Hematological remission was associated with improved neutrophil migration profiles, but these ultimately normalized only after hematopoietic cell transplantation. Five patients were followed up for long-term effects of hematopoietic cell transplantation for up to 24 mo. This is the first longitudinal ex vivo neutrophil migration study in patients with acute myeloid leukemia, followed by allogeneic hematopoietic cell transplantation. It identified functional neutrophil impairments beyond routine quantitative assessments, adding to the well-known quantitative impairment of neutropenia. HCT can reestablish functional neutrophils with healthy migration profiles in these patients.
000298928 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000298928 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000298928 650_7 $$2Other$$aacute myeloid leukemia
000298928 650_7 $$2Other$$amyeloid neoplasia
000298928 650_7 $$2Other$$aneutrophil granulocytes
000298928 650_7 $$2Other$$atransplantation
000298928 650_2 $$2MeSH$$aHumans
000298928 650_2 $$2MeSH$$aLeukemia, Myeloid, Acute: therapy
000298928 650_2 $$2MeSH$$aLeukemia, Myeloid, Acute: immunology
000298928 650_2 $$2MeSH$$aLeukemia, Myeloid, Acute: pathology
000298928 650_2 $$2MeSH$$aNeutrophils: immunology
000298928 650_2 $$2MeSH$$aNeutrophils: pathology
000298928 650_2 $$2MeSH$$aMale
000298928 650_2 $$2MeSH$$aFemale
000298928 650_2 $$2MeSH$$aMiddle Aged
000298928 650_2 $$2MeSH$$aNeutropenia: etiology
000298928 650_2 $$2MeSH$$aNeutropenia: pathology
000298928 650_2 $$2MeSH$$aNeutropenia: immunology
000298928 650_2 $$2MeSH$$aAdult
000298928 650_2 $$2MeSH$$aHematopoietic Stem Cell Transplantation: adverse effects
000298928 650_2 $$2MeSH$$aAged
000298928 650_2 $$2MeSH$$aTransplantation, Homologous: adverse effects
000298928 650_2 $$2MeSH$$aCell Movement
000298928 650_2 $$2MeSH$$aYoung Adult
000298928 7001_ $$aBeer, Alexander$$b1
000298928 7001_ $$aKraus, Andreas$$b2
000298928 7001_ $$aPillibeit, Aleksandra$$b3
000298928 7001_ $$aBludau, Dana$$b4
000298928 7001_ $$aAbdulla, Haji$$b5
000298928 7001_ $$aNeuendorff, Nina Rosa$$b6
000298928 7001_ $$aSonneck, Justin$$b7
000298928 7001_ $$aKowitz, Lennart$$b8
000298928 7001_ $$aRiese, Stefanie$$b9
000298928 7001_ $$aTuz, Ali Ata$$b10
000298928 7001_ $$aChen, Jianxu$$b11
000298928 7001_ $$aCherneha, Maxim$$b12
000298928 7001_ $$aBeelen, Dietrich W$$b13
000298928 7001_ $$0P:(DE-HGF)0$$aReinhardt, H Christian$$b14
000298928 7001_ $$00000-0002-5534-6055$$aGunzer, Matthias$$b15
000298928 7001_ $$00000-0003-1347-3360$$aTurki, Amin T$$b16
000298928 773__ $$0PERI:(DE-600)2026833-6$$a10.1093/jleuko/qiae250$$gVol. 117, no. 2, p. qiae250$$n2$$pqiae250$$tJournal of leukocyte biology$$v117$$x0741-5400$$y2025
000298928 909CO $$ooai:inrepo02.dkfz.de:298928$$pVDB
000298928 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000298928 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-1347-3360$$aDeutsches Krebsforschungszentrum$$b16$$kDKFZ
000298928 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000298928 9141_ $$y2025
000298928 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2024-12-12$$wger
000298928 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ LEUKOCYTE BIOL : 2022$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-12
000298928 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ LEUKOCYTE BIOL : 2022$$d2024-12-12
000298928 9201_ $$0I:(DE-He78)ED01-20160331$$kED01$$lDKTK Koordinierungsstelle Essen/Düsseldorf$$x0
000298928 980__ $$ajournal
000298928 980__ $$aVDB
000298928 980__ $$aI:(DE-He78)ED01-20160331
000298928 980__ $$aUNRESTRICTED