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@ARTICLE{Cibir:298928,
      author       = {Z. Cibir and A. Beer and A. Kraus and A. Pillibeit and D.
                      Bludau and H. Abdulla and N. R. Neuendorff and J. Sonneck
                      and L. Kowitz and S. Riese and A. A. Tuz and J. Chen and M.
                      Cherneha and D. W. Beelen and H. C. Reinhardt$^*$ and M.
                      Gunzer and A. T. Turki$^*$},
      title        = {{R}isk beyond neutropenia: insights into neutrophil
                      migration from newly diagnosed {AML} until late after
                      allogeneic stem cell transplantation.},
      journal      = {Journal of leukocyte biology},
      volume       = {117},
      number       = {2},
      issn         = {0741-5400},
      address      = {Tokyo},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2025-00362},
      pages        = {qiae250},
      year         = {2025},
      abstract     = {Quantification of neutrophil counts is the most relevant
                      assessment of cellular immunity in clinical practice.
                      Patients with neutropenia are considered at risk and are
                      categorized according to its severity. The incidence of
                      febrile neutropenia varies, but patients with acute myeloid
                      leukemia are traditionally considered at high risk,
                      especially following myelotoxic treatments. To provide
                      additional functional parameters, we investigated the ex
                      vivo migration properties and morphology of neutrophils in
                      10 patients with acute myeloid leukemia using single-cell
                      video-microscopy and discovered, in addition to neutropenia,
                      highly pathological neutrophil migration patterns and
                      polarization defects in patients with untreated acute
                      myeloid leukemia. Neutrophil speed was the most sensitive
                      parameter and significantly lower at leukemia diagnosis
                      (9.067 vs 15.810 µm/min, P = 0.0025) compared to healthy
                      controls (n = 46). Hematological remission was associated
                      with improved neutrophil migration profiles, but these
                      ultimately normalized only after hematopoietic cell
                      transplantation. Five patients were followed up for
                      long-term effects of hematopoietic cell transplantation for
                      up to 24 mo. This is the first longitudinal ex vivo
                      neutrophil migration study in patients with acute myeloid
                      leukemia, followed by allogeneic hematopoietic cell
                      transplantation. It identified functional neutrophil
                      impairments beyond routine quantitative assessments, adding
                      to the well-known quantitative impairment of neutropenia.
                      HCT can reestablish functional neutrophils with healthy
                      migration profiles in these patients.},
      keywords     = {Humans / Leukemia, Myeloid, Acute: therapy / Leukemia,
                      Myeloid, Acute: immunology / Leukemia, Myeloid, Acute:
                      pathology / Neutrophils: immunology / Neutrophils: pathology
                      / Male / Female / Middle Aged / Neutropenia: etiology /
                      Neutropenia: pathology / Neutropenia: immunology / Adult /
                      Hematopoietic Stem Cell Transplantation: adverse effects /
                      Aged / Transplantation, Homologous: adverse effects / Cell
                      Movement / Young Adult / acute myeloid leukemia (Other) /
                      myeloid neoplasia (Other) / neutrophil granulocytes (Other)
                      / transplantation (Other)},
      cin          = {ED01},
      ddc          = {570},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39953806},
      doi          = {10.1093/jleuko/qiae250},
      url          = {https://inrepo02.dkfz.de/record/298928},
}