TY  - JOUR
AU  - Launspach, Michael
AU  - Mindermann, Aurika
AU  - Schulz, Joachim
AU  - Alasfar, Lina
AU  - Cyrull, Sandra
AU  - Zirngibl, Felix
AU  - Oevermann, Lena
AU  - Künkele, Annette
AU  - Deubzer, Hedwig E
AU  - von Bernuth, Horst
AU  - Pruß, Axel
AU  - Lang, Peter
AU  - Bufler, Philip
AU  - Eggert, Angelika
AU  - von Stackelberg, Arend
AU  - Schulte, Johannes
TI  - High Incidence and Impact of Suspected Exocrine Pancreatic Insufficiency in Patients Post-Hematopoietic Stem Cell Transplantation: A Single-Center Prospective Observational Study.
JO  - United european gastroenterology journal
VL  - 13
IS  - 2
SN  - 2050-6406
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-00367
SP  - 257-267
PY  - 2025
N1  - 2025 Mar;13(2):257-267
AB  - Exocrine pancreatic insufficiency (EPI) is suspected but remains understudied in immunosuppressed conditions such as post-hematopoietic stem cell transplantation (HSCT). This prospective observational study aimed to investigate the incidence, impact, and risk factors of EPI in a cohort of 83 pediatric and young adult patients who underwent allogeneic HSCT at Charité - Universitätsmedizin Berlin between 2020 and 2023. Fecal pancreatic elastase (PE) measurements and transabdominal ultrasound were utilized to evaluate pancreatic function over a one-year period. Secondary analysis explored the association of EPI with clinical complications and included a multivariable regression analysis of potential risk factors. Low PE levels significantly correlated with pathological pancreatic imaging findings, independent of concurrent diarrhea. EPI was suspected in 45
KW  - adenovirus infection (Other)
KW  - bone marrow transplantation (Other)
KW  - exocrine pancreas function (Other)
KW  - fecal elastase (Other)
KW  - immunosuppression (Other)
KW  - pancreas elastase (Other)
KW  - pancreas imaging (Other)
KW  - pancreas ultrasound (Other)
KW  - pancreatitis (Other)
KW  - stem cell transplantation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39955611
DO  - DOI:10.1002/ueg2.12769
UR  - https://inrepo02.dkfz.de/record/298933
ER  -