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@ARTICLE{Galuzzi:298939,
      author       = {L. Galuzzi and G. Parisi and V. Pascali and M. Niklas$^*$
                      and D. Bortot and N. Protti and S. Altieri},
      title        = {{F}luorescent {N}eutron {T}rack {D}etectors for {B}oron-10
                      {M}icrodistribution {M}easurement in {BNCT}: {A}
                      {F}easibility {S}tudy.},
      journal      = {Materials},
      volume       = {18},
      number       = {3},
      issn         = {1996-1944},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2025-00373},
      pages        = {621},
      year         = {2025},
      note         = {Division of Radiology and Division of Medical Physics in
                      Radiation Oncology, DKFZ},
      abstract     = {Boron Neutron-Capture Therapy (BNCT) is a form of radiation
                      therapy that relies on the highly localized and enhanced
                      biological effects of the 10B neutron capture (BNC) reaction
                      products to selectively kill cancer cells. The efficacy of
                      BNCT is, therefore, strongly dependent on the 10B spatial
                      microdistribution at a subcellular level. Fluorescent
                      Nuclear Track Detectors (FNTDs) could be a promising
                      technology for measuring 10B microdistribution. They allow
                      the measurement of the tracks of charged particles, and
                      their biocompatibility allows cell samples to be deposited
                      and grown on their surfaces. If a layer of borated cells is
                      deposited and irradiated by a neutron field, the energy
                      deposited by the BNC products and their trajectories can be
                      measured by analyzing the corresponding tracks. This allows
                      the reconstruction of the position where the measured
                      particles were generated, hence the microdistribution of
                      10B. With respect to other techniques developed to measure
                      10B microdistribution, FNTDs would be a non-destructive,
                      biocompatible, relatively easy-to-use, and accessible
                      method, allowing the simultaneous measurement of the 10B
                      microdistribution, the LET of particles, and the evolution
                      of the related biological response on the very same cell
                      sample. An FNTD was tested in three irradiation conditions
                      to study the feasibility of FNTDs for BNCT applications. The
                      FNTD allowed the successful measurement of the correct alpha
                      particle range and mean penetration depth expected for all
                      the radiation fields employed. This work proved the
                      feasibility of FNTD in reconstructing the tracks of the
                      alpha particles produced in typical BNCT conditions, thus
                      the 10B microdistribution. Further experiments are planned
                      at the University of Pavia's LENA (Applied Nuclear Energy
                      Laboratory) to test the final set-up coupling the FNTD with
                      borated cell samples.},
      keywords     = {BNCT (Other) / Fluorescent Nuclear Track Detector (Other) /
                      boron microdistribution (Other) / particle track (Other)},
      cin          = {E010 / E041},
      ddc          = {600},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39942287},
      pmc          = {pmc:PMC11818730},
      doi          = {10.3390/ma18030621},
      url          = {https://inrepo02.dkfz.de/record/298939},
}