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@ARTICLE{Wulff:298949,
      author       = {J. Wulff and B. Koska and M. Giese and C. Bäumer$^*$ and
                      R. Richter and A. Foerster and N. E. Bechrakis and B.
                      Timmermann$^*$},
      title        = {{E}valuation of {OPTOS} wide-field fundus image projections
                      for radiotherapy planning of uveal melanoma.},
      journal      = {Journal of applied clinical medical physics},
      volume       = {26},
      number       = {4},
      issn         = {1526-9914},
      address      = {Reston, Va.},
      publisher    = {ACMP},
      reportid     = {DKFZ-2025-00383},
      pages        = {e70009},
      year         = {2025},
      note         = {2025 Apr;26(4):e70009},
      abstract     = {To investigate the relationship between the stereographic
                      and azimuthal equidistant projection (AEP) of the human
                      retina for radiotherapy planning with OPTOS optomap
                      wide-field fundus images (Optos, UK). Further, the geometric
                      accuracy of an OPTOS fundus image is quantified.The
                      fundamental relationship between both projection modes was
                      applied to transform images acquired with an OPTOS
                      Silverstone camera to the azimuthal equidistant projection
                      using MATLAB. Fundus images of four patients were used to
                      quantitatively demonstrate the impact for neglecting the
                      proper projection. For that purpose, a delineated contour
                      for each patient was analyzed if created in a treatment
                      planning system, which assumes AEP, and compared with an
                      OPTOS image. Furthermore, an eye model with a novel 3D
                      printed retina pattern was used to quantify the geometric
                      accuracy for an OPTOS optomap image.The difference between
                      both projections was found substantial, leading to a change
                      in delineated contours of more than 5 mm in the investigated
                      cases and a change of delineated area of more than $40\%.$
                      The geometric accuracy of OPTOS images of a customized eye
                      model was found to be 0.2 mm on average, increasing to at
                      most ∼0.5 mm at eye angles of 81°.The fundamental
                      difference in the representation of the eye fundus needs to
                      be accounted for in radiotherapy planning of uveal melanoma.
                      The basic underlying relationship for transformation is
                      known, but more research is required to quantify other
                      aberrations. The novel use of 3D printed retina patterns
                      with known dimensions is providing a flexible approach for
                      further investigations.},
      keywords     = {3D printing (Other) / Fundus imaging (Other) / proton
                      therapy (Other)},
      cin          = {ED01},
      ddc          = {530},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39962748},
      doi          = {10.1002/acm2.70009},
      url          = {https://inrepo02.dkfz.de/record/298949},
}