TY  - JOUR
AU  - Hoffmeister-Wittmann, Paula
AU  - Hoegen-Saßmannshausen, Philipp
AU  - Wicklein, Livia
AU  - Weykamp, Fabian
AU  - Seidensaal, Katharina
AU  - Springfeld, Christoph
AU  - Dill, Michael
AU  - Longerich, Thomas
AU  - Schirmacher, Peter
AU  - Mehrabi, Arianeb
AU  - Mathy, René Michael
AU  - Köhler, Bruno C
AU  - Debus, Jürgen
AU  - Herfarth, Klaus
AU  - Liermann, Jakob
TI  - Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer.
JO  - Radiation oncology
VL  - 20
IS  - 1
SN  - 1748-717X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00396
SP  - 23
PY  - 2025
AB  - Liver cancer is the third leading cause of cancer related death due to treatment resistance and late onset of symptoms (Rumgay in J Hepatol 77: 1598-1606, 2022). The role of external beam radiotherapy (EBRT) in treatment of unresectable liver cancer needs to be defined. The use of particle therapy such as carbon ion radiation therapy (CIRT) with high linear energy transfer (LET) could increase efficacy of EBRT while limiting the toxic effects of radiation on non-cancerous liver tissue. Promising effects of CIRT have been described in several studies during the past decades, mostly in Japan. To date, no standardized treatment protocol has been established and European data on CIRT for liver cancer is lacking. This retrospective analysis aims to investigate efficacy and safety of hypofractionated CIRT compared to photon-based stereotactic body radiation (SBRT) in primary liver cancer.Thirty-six (n = 36) and twenty (n = 20) patients with primary malignant liver tumors were treated with hypofractionated CIRT (4 fractions) and photon-based SBRT, respectively, between 2011 and 2022 and were retrospectively evaluated for survival, local control, and toxicity.Two-year local control rate after CIRT was 92.3
KW  - Humans
KW  - Liver Neoplasms: radiotherapy
KW  - Radiosurgery: adverse effects
KW  - Radiosurgery: methods
KW  - Retrospective Studies
KW  - Heavy Ion Radiotherapy: adverse effects
KW  - Aged
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Aged, 80 and over
KW  - Survival Rate
KW  - Adult
KW  - Carcinoma, Hepatocellular: radiotherapy
KW  - Carcinoma, Hepatocellular: mortality
KW  - Carcinoma, Hepatocellular: pathology
KW  - Carbon ion radiotherapy (Other)
KW  - Cholangiocarcinoma (Other)
KW  - Hepatocellular carcinoma (Other)
KW  - Hypofractionation (Other)
KW  - Local control (Other)
KW  - SBRT (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39966902
DO  - DOI:10.1186/s13014-025-02594-y
UR  - https://inrepo02.dkfz.de/record/298967
ER  -