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@ARTICLE{Abooali:299000,
      author       = {M. Abooali and S. Schlichtner$^*$ and X. Lei and N. Aliu
                      and S. Ruggiero and S. Loges$^*$ and M. Ziegler$^*$ and F.
                      Hertel$^*$ and A.-L. Volckmar and A. Stenzinger and P.
                      Christopoulos and M. Thomas and E. Klenova and N. H. Meyer
                      and S. Boussios and N. Heaton and Y. Zen and A. Zamalloa and
                      S. Chokshi and L. Urbani and S. Richard and K. Kirubendran
                      and R. Hussain and G. Siligardi and D. Cholewa and S. M.
                      Berger and I. M. Yasinska and E. Fasler-Kan and V. V.
                      Sumbayev},
      title        = {{I}ntracellular and extracellular activities of {V}-domain
                      {I}g-containing suppressor of {T} cell activation ({VISTA})
                      modulated by immunosuppressive factors of tumour
                      microenvironment.},
      journal      = {Cancer letters},
      volume       = {616},
      issn         = {0304-3835},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-00410},
      pages        = {217581},
      year         = {2025},
      note         = {2025 Apr 28;616:217581},
      abstract     = {V-domain Ig-containing suppressor of T cell activation
                      (VISTA) is a unique immune checkpoint protein, which was
                      reported to display both receptor and ligand activities.
                      However, the mechanisms of regulation of VISTA activity and
                      functions by factors of tumour microenvironment (TME) remain
                      unclear and understanding these processes is required in
                      order to develop successful personalised cancer
                      immunotherapeutic strategies and approaches. Here we report
                      for the very first time that VISTA interacts with another
                      immune checkpoint protein galectin-9 inside the cell most
                      likely facilitating its interaction with TGF-β-activated
                      kinase 1 (TAK1). This process is required for protection of
                      lysosomes, which is crucial for many cell types and tissues.
                      We found that VISTA expression can be differentially
                      controlled by crucial factors present in TME, such as
                      transforming growth factor beta type 1 (TGF-β) and hypoxia
                      as well as other factors activating hypoxic signalling. We
                      confirmed that involvement of these important pathways
                      modulated by TME differentially influences VISTA expression
                      in different cell types. These networks include:
                      TGF-β-Smad3 pathway, TAK1 (TGF-β-activated kinase 1) or
                      apoptosis signal-regulating kinase 1 (ASK1)-induced
                      activation of activating transcription factor 2 (ATF-2) and
                      hypoxic signalling pathway. Based on this work we determined
                      the five critical functions of VISTA and the role of TME
                      factors in controlling (modulating or downregulating) VISTA
                      expression.},
      cin          = {A420},
      ddc          = {570},
      cid          = {I:(DE-He78)A420-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39983894},
      doi          = {10.1016/j.canlet.2025.217581},
      url          = {https://inrepo02.dkfz.de/record/299000},
}