% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Gupta:299003,
      author       = {S. Gupta and G. K. Bajwa and H. El-Sammak$^*$ and K.
                      Mattonet and S. Günther and M. Looso and D. Y. R. Stainier
                      and R. Marín-Juez},
      title        = {{T}he transmembrane glycoprotein {G}pnmb is required for
                      the immune and fibrotic responses during zebrafish heart
                      regeneration.},
      journal      = {Developmental biology},
      volume       = {521},
      issn         = {0012-1606},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00413},
      pages        = {153-162},
      year         = {2025},
      note         = {2025 May;521:153-162},
      abstract     = {Myocardial infarction occurs when the coronary supply of
                      oxygen and nutrients to part of the heart is interrupted. In
                      contrast to adult mammals, adult zebrafish have a remarkable
                      ability to regenerate their heart after cardiac injury.
                      Several processes are involved in this regenerative response
                      including inflammation, coronary endothelial cell
                      proliferation and revascularization, endocardial expansion,
                      cardiomyocyte repopulation, and transient scar formation. To
                      identify additional regulators of zebrafish cardiac
                      regeneration, we profiled the transcriptome of regenerating
                      coronary endothelial cells at 7 days post cryoinjury (dpci)
                      and observed the significant upregulation of dozens of genes
                      including gpnmb. Gpnmb (glycoprotein non-metastatic melanoma
                      protein B) is a transmembrane glycoprotein implicated in
                      inflammation resolution and tissue regeneration.
                      Transcriptomic profiling data of cryoinjured zebrafish
                      hearts reveal that gpnmb is mostly expressed by macrophages.
                      To investigate gpnmb function during zebrafish cardiac
                      regeneration, we generated a full locus deletion allele. We
                      find that after cardiac cryoinjury, animals lacking gpnmb
                      exhibit neutrophil retention and decreased macrophage
                      recruitment as well as reduced myofibroblast numbers.
                      Moreover, loss of gpnmb impairs coronary endothelial cell
                      regeneration and cardiomyocyte dedifferentiation.
                      Transcriptomic analyses of cryoinjured gpnmb-/- hearts
                      identified enhanced collagen gene expression and the
                      activation of extracellular matrix (ECM) related pathways.
                      Furthermore, gpnmb-/- hearts exhibit larger fibrotic scars
                      revealing additional defects in cardiac regeneration.
                      Altogether, these data indicate that gpnmb, which is mostly
                      expressed by macrophages, modulates inflammation and ECM
                      deposition after cardiac cryoinjury in zebrafish and further
                      highlight the importance of these immune cells during
                      regeneration.},
      keywords     = {Zebrafish (Other) / cardiac regeneration (Other) / coronary
                      (Other) / gpnmb (Other) / macrophages (Other)},
      cin          = {A290},
      ddc          = {570},
      cid          = {I:(DE-He78)A290-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39983908},
      doi          = {10.1016/j.ydbio.2025.02.011},
      url          = {https://inrepo02.dkfz.de/record/299003},
}