%0 Journal Article
%A Alduhayh, Saleh
%A Laskar, Ruhina Shirin
%A Jiang, Xia
%A Zhu, Zhaozhong
%A Vincent, Emma E
%A Constantinescu, Andrei-Emil
%A Buchanan, Daniel D
%A Grant, Robert C
%A Phipps, Amanda I
%A Brenner, Hermann
%A Huang, Wen-Yi
%A Kweon, Sun-Seog
%A Li, Li
%A Pearlman, Rachel
%A Castellví-Bel, Sergi
%A Gruber, Stephen B
%A Li, Christopher I
%A Pellatt, Andrew
%A Platz, Elizabeth A
%A Van Guelpen, Bethany
%A Zheng, Wei
%A Chan, Andrew T
%A Figueiredo, Jane C
%A Ogino, Shuji
%A Ulrich, Cornelia M
%A Gunter, Marc J
%A Haycock, Philip
%A Severi, Gianluca
%A Murphy, Neil
%A Dimou, Niki
%T Association of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a Mendelian randomization study.
%J Cancer epidemiology, biomarkers & prevention
%V 34
%N 5
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2025-00415
%P 722-736
%D 2025
%Z 2025 May 2;34(5):722-736
%X Tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with risk of overall and early-onset colorectal cancer.Genome-wide association study summary statistic data were used to identify genetic variants associated with allergic diseases (Nvariants=65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases=52,775 cases) and early-onset colorectal cancer (Ncases=6,176). The mediating role of white blood cells was examined using multivariable MR.In inverse-variance weighted models, genetic liability to allergic diseases was inversely associated with overall (ORper log(odds)= 0.90 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39982694
%R 10.1158/1055-9965.EPI-24-0970
%U https://inrepo02.dkfz.de/record/299005