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000299005 1001_ $$00009-0008-6142-521X$$aAlduhayh, Saleh$$b0
000299005 245__ $$aAssociation of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a Mendelian randomization study.
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000299005 520__ $$aTumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with risk of overall and early-onset colorectal cancer.Genome-wide association study summary statistic data were used to identify genetic variants associated with allergic diseases (Nvariants=65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases=52,775 cases) and early-onset colorectal cancer (Ncases=6,176). The mediating role of white blood cells was examined using multivariable MR.In inverse-variance weighted models, genetic liability to allergic diseases was inversely associated with overall (ORper log(odds)= 0.90 [95% CI= 0.85-0.96]; P< 0.01) and early-onset colorectal cancer (OR= 0.83 [95% CI= 0.73-0.95]; P= 0.01). Similar inverse associations were found for hay fever/allergic rhinitis or eczema, while no evidence of association was found between liability to asthma-related phenotypes and colorectal cancer risk. Multivariable MR adjustment for eosinophils weakened the inverse associations for liability to allergic diseases for overall (OR= 0.96 [95% CI= 0.89-1.03]; P= 0.26) and early-onset colorectal cancer (OR= 0.86 [95% CI= 0.73-1.01]; P= 0.06).Our study supports a potential causal association between liability to allergic diseases, specifically hay fever/allergic rhinitis or eczema, and colorectal cancer, possibly at least in part mediated via eosinophil counts.Our results provide evidence that allergic responses may also have a role in immunosurveillance against colorectal cancer.
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000299005 7001_ $$00000-0001-6455-094X$$aLaskar, Ruhina Shirin$$b1
000299005 7001_ $$aJiang, Xia$$b2
000299005 7001_ $$00000-0001-5662-1541$$aZhu, Zhaozhong$$b3
000299005 7001_ $$00000-0002-8917-7384$$aVincent, Emma E$$b4
000299005 7001_ $$00000-0002-7974-5245$$aConstantinescu, Andrei-Emil$$b5
000299005 7001_ $$00000-0003-2225-6675$$aBuchanan, Daniel D$$b6
000299005 7001_ $$00000-0002-9821-0377$$aGrant, Robert C$$b7
000299005 7001_ $$00000-0002-1446-2201$$aPhipps, Amanda I$$b8
000299005 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b9$$udkfz
000299005 7001_ $$aHuang, Wen-Yi$$b10
000299005 7001_ $$00000-0003-2378-8550$$aKweon, Sun-Seog$$b11
000299005 7001_ $$aLi, Li$$b12
000299005 7001_ $$00000-0002-9293-5860$$aPearlman, Rachel$$b13
000299005 7001_ $$00000-0003-1217-5097$$aCastellví-Bel, Sergi$$b14
000299005 7001_ $$00000-0001-8656-7822$$aGruber, Stephen B$$b15
000299005 7001_ $$00000-0003-1543-0743$$aLi, Christopher I$$b16
000299005 7001_ $$00000-0002-0127-9790$$aPellatt, Andrew$$b17
000299005 7001_ $$00000-0003-3676-8954$$aPlatz, Elizabeth A$$b18
000299005 7001_ $$00000-0002-9692-101X$$aVan Guelpen, Bethany$$b19
000299005 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b20
000299005 7001_ $$00000-0001-7284-6767$$aChan, Andrew T$$b21
000299005 7001_ $$00000-0001-8040-3341$$aFigueiredo, Jane C$$b22
000299005 7001_ $$00000-0002-3909-2323$$aOgino, Shuji$$b23
000299005 7001_ $$00000-0001-7641-059X$$aUlrich, Cornelia M$$b24
000299005 7001_ $$00000-0001-5472-6761$$aGunter, Marc J$$b25
000299005 7001_ $$00000-0001-5001-3350$$aHaycock, Philip$$b26
000299005 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b27
000299005 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b28
000299005 7001_ $$00000-0003-1678-9328$$aDimou, Niki$$b29
000299005 773__ $$0PERI:(DE-600)2036781-8$$a10.1158/1055-9965.EPI-24-0970$$n5$$p722-736$$tCancer epidemiology, biomarkers & prevention$$v34$$x1055-9965$$y2025
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