TY  - JOUR
AU  - Alduhayh, Saleh
AU  - Laskar, Ruhina Shirin
AU  - Jiang, Xia
AU  - Zhu, Zhaozhong
AU  - Vincent, Emma E
AU  - Constantinescu, Andrei-Emil
AU  - Buchanan, Daniel D
AU  - Grant, Robert C
AU  - Phipps, Amanda I
AU  - Brenner, Hermann
AU  - Huang, Wen-Yi
AU  - Kweon, Sun-Seog
AU  - Li, Li
AU  - Pearlman, Rachel
AU  - Castellví-Bel, Sergi
AU  - Gruber, Stephen B
AU  - Li, Christopher I
AU  - Pellatt, Andrew
AU  - Platz, Elizabeth A
AU  - Van Guelpen, Bethany
AU  - Zheng, Wei
AU  - Chan, Andrew T
AU  - Figueiredo, Jane C
AU  - Ogino, Shuji
AU  - Ulrich, Cornelia M
AU  - Gunter, Marc J
AU  - Haycock, Philip
AU  - Severi, Gianluca
AU  - Murphy, Neil
AU  - Dimou, Niki
TI  - Association of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a Mendelian randomization study.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 34
IS  - 5
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2025-00415
SP  - 722-736
PY  - 2025
N1  - 2025 May 2;34(5):722-736
AB  - Tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with risk of overall and early-onset colorectal cancer.Genome-wide association study summary statistic data were used to identify genetic variants associated with allergic diseases (Nvariants=65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases=52,775 cases) and early-onset colorectal cancer (Ncases=6,176). The mediating role of white blood cells was examined using multivariable MR.In inverse-variance weighted models, genetic liability to allergic diseases was inversely associated with overall (ORper log(odds)= 0.90 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:39982694
DO  - DOI:10.1158/1055-9965.EPI-24-0970
UR  - https://inrepo02.dkfz.de/record/299005
ER  -