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@ARTICLE{Alduhayh:299005,
      author       = {S. Alduhayh and R. S. Laskar and X. Jiang and Z. Zhu and E.
                      E. Vincent and A.-E. Constantinescu and D. D. Buchanan and
                      R. C. Grant and A. I. Phipps and H. Brenner$^*$ and W.-Y.
                      Huang and S.-S. Kweon and L. Li and R. Pearlman and S.
                      Castellví-Bel and S. B. Gruber and C. I. Li and A. Pellatt
                      and E. A. Platz and B. Van Guelpen and W. Zheng and A. T.
                      Chan and J. C. Figueiredo and S. Ogino and C. M. Ulrich and
                      M. J. Gunter and P. Haycock and G. Severi and N. Murphy and
                      N. Dimou},
      title        = {{A}ssociation of genetic liability to allergic diseases
                      with overall and early-onset colorectal cancer risk: a
                      {M}endelian randomization study.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {34},
      number       = {5},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2025-00415},
      pages        = {722-736},
      year         = {2025},
      note         = {2025 May 2;34(5):722-736},
      abstract     = {Tumor immunosurveillance theory supports that allergic
                      conditions could decrease cancer risk. However,
                      observational evidence yielded inconsistent results for the
                      association between allergic diseases and colorectal cancer
                      risk. We used Mendelian randomization (MR) to examine
                      potential causal associations of allergies with risk of
                      overall and early-onset colorectal cancer.Genome-wide
                      association study summary statistic data were used to
                      identify genetic variants associated with allergic diseases
                      (Nvariants=65) and individual allergic conditions (asthma,
                      hay fever/allergic rhinitis, eczema). Using two-sample MR,
                      we examined these variants in relation to incident overall
                      (Ncases=52,775 cases) and early-onset colorectal cancer
                      (Ncases=6,176). The mediating role of white blood cells was
                      examined using multivariable MR.In inverse-variance weighted
                      models, genetic liability to allergic diseases was inversely
                      associated with overall (ORper log(odds)= 0.90 $[95\%$ CI=
                      0.85-0.96]; P< 0.01) and early-onset colorectal cancer (OR=
                      0.83 $[95\%$ CI= 0.73-0.95]; P= 0.01). Similar inverse
                      associations were found for hay fever/allergic rhinitis or
                      eczema, while no evidence of association was found between
                      liability to asthma-related phenotypes and colorectal cancer
                      risk. Multivariable MR adjustment for eosinophils weakened
                      the inverse associations for liability to allergic diseases
                      for overall (OR= 0.96 $[95\%$ CI= 0.89-1.03]; P= 0.26) and
                      early-onset colorectal cancer (OR= 0.86 $[95\%$ CI=
                      0.73-1.01]; P= 0.06).Our study supports a potential causal
                      association between liability to allergic diseases,
                      specifically hay fever/allergic rhinitis or eczema, and
                      colorectal cancer, possibly at least in part mediated via
                      eosinophil counts.Our results provide evidence that allergic
                      responses may also have a role in immunosurveillance against
                      colorectal cancer.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39982694},
      doi          = {10.1158/1055-9965.EPI-24-0970},
      url          = {https://inrepo02.dkfz.de/record/299005},
}