TY  - JOUR
AU  - Schock, Lisa
AU  - Wrede, Karsten
AU  - Oezkan, Neriman
AU  - Dammann, Philipp
AU  - Oppong, Marvin Darkwah
AU  - Gembruch, Oliver
AU  - Jabbarli, Ramazan
AU  - Kreitschmann-Andermahr, Ilonka
AU  - Siegel, Sonja
AU  - Friedel, Anna Lena
AU  - Engel, Adrian
AU  - Karadachi, Hanah Hadice
AU  - Laflör, Lilith Philomena
AU  - Sure, Ulrich
AU  - Ahmadipour, Yahya
TI  - Comparison of Subjective and Objective Cognitive Function and Emotional State in Supratentorial Brain Tumors Before Surgery-Recognizing the Influence of Laterality.
JO  - Cancer medicine
VL  - 14
IS  - 4
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-00416
SP  - e70721
PY  - 2025
AB  - Because of its high prognostic value, neuropsychological assessment plays a crucial role in the neuro-oncology setting. Subjective and objective cognitive performance correlate only to a limited extent, and subjective cognitive performance is strongly dependent on emotional state. We postulate that the relation of subjective and objective cognitive performance depends on tumor laterality.In this prospective study, N = 63 patients with brain tumors underwent a neuropsychological test battery, including assessment of subjective cognitive function (attention, memory, executive), and symptoms of depression and anxiety before surgery. Patients with psychiatric comorbidity or severe neurological conditions were excluded.There were no significant differences in subjective and objective cognitive function, symptoms of depression and anxiety between left (N = 37) and right (N = 26) hemisphere tumors. All measures of subjective cognitive function correlated highly significantly with symptoms of depression and anxiety in left hemisphere tumor patients (all r ≥ 0.470). In right hemisphere tumor patients, there was no relation between subjective cognitive function and emotional state. Significant laterality differences for correlations of subjective and objective cognitive function were not found and were not significant within the two groups.Even when unbiased by symptoms of anxiety and depression, right hemisphere tumor patients show the same discrepancy in subjective and objective cognitive function as left hemisphere tumor patients. This discrepancy may be based on a different mechanism in right hemisphere tumor patients.
KW  - Humans
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Emotions
KW  - Cognition
KW  - Neuropsychological Tests
KW  - Anxiety: psychology
KW  - Prospective Studies
KW  - Depression: psychology
KW  - Depression: etiology
KW  - Adult
KW  - Aged
KW  - Supratentorial Neoplasms: surgery
KW  - Supratentorial Neoplasms: psychology
KW  - Functional Laterality
KW  - anxiety (Other)
KW  - brain tumor (Other)
KW  - depression (Other)
KW  - laterality (Other)
KW  - subjective cognitive function (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39980309
C2  - pmc:PMC11842867
DO  - DOI:10.1002/cam4.70721
UR  - https://inrepo02.dkfz.de/record/299006
ER  -