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000299007 1001_ $$00000-0003-4504-2012$$aBender, Tamara$$b0
000299007 245__ $$aAberrant choroid plexus formation drives the development of treatment-related brain toxicity.
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000299007 520__ $$aBrain tumors are commonly treated with radiotherapy, but the efficacy of the treatment is limited by its toxicity to the normal tissue including post-irradiation contrast enhanced lesions often linked to necrosis. The poorly understood mechanisms behind such brain lesions were studied using cerebral organoids. Here we show that irradiation of such organoids leads to dose-dependent growth retardation and formation of liquid-filled cavities but is not correlated with necrosis. Instead, the radiation-induced changes comprise of an enhancement of cortical hem markers, altered neuroepithelial stem cell differentiation, and an increase of ZO1+/AQP1+/CLDN3+-choroid plexus (CP)-like structures accompanied by an upregulation of IGF2 mRNA, known to be expressed in CP and cerebrospinal fluid. The altered differentiation is attributed to changes in the WNT/BMP signaling pathways. We conclude that aberrant CP formation can be involved in radiation-induced brain lesions providing additional strategies for possible countermeasures.
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000299007 650_2 $$2MeSH$$aChoroid Plexus: metabolism
000299007 650_2 $$2MeSH$$aChoroid Plexus: radiation effects
000299007 650_2 $$2MeSH$$aAnimals
000299007 650_2 $$2MeSH$$aOrganoids: metabolism
000299007 650_2 $$2MeSH$$aMice
000299007 650_2 $$2MeSH$$aBrain Neoplasms: genetics
000299007 650_2 $$2MeSH$$aBrain Neoplasms: pathology
000299007 650_2 $$2MeSH$$aBrain Neoplasms: metabolism
000299007 650_2 $$2MeSH$$aBrain: metabolism
000299007 650_2 $$2MeSH$$aBrain: radiation effects
000299007 650_2 $$2MeSH$$aBrain: pathology
000299007 650_2 $$2MeSH$$aHumans
000299007 650_2 $$2MeSH$$aCell Differentiation
000299007 650_2 $$2MeSH$$aWnt Signaling Pathway
000299007 7001_ $$00009-0005-5088-7927$$aSchickel, Esther$$b1
000299007 7001_ $$aSchielke, Celine$$b2
000299007 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b3$$udkfz
000299007 7001_ $$00009-0001-4569-7548$$aGrosshans, David R$$b4
000299007 7001_ $$00000-0002-4615-553X$$aDurante, Marco$$b5
000299007 7001_ $$00000-0002-3957-7099$$aSchroeder, Insa S$$b6
000299007 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-025-07736-2$$gVol. 8, no. 1, p. 276$$n1$$p276$$tCommunications biology$$v8$$x2399-3642$$y2025
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