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@ARTICLE{Ector:299469,
      author       = {C. Ector and J. Didier and S. De Landtsheer and M. S.
                      Nordentoft and C. Schmal and U. Keilholz$^*$ and H. Herzel
                      and A. Kramer and T. Sauter and A. E. Granada$^*$},
      title        = {{C}ircadian clock features define novel subtypes among
                      breast cancer cells and shape drug sensitivity.},
      journal      = {Molecular systems biology},
      volume       = {21},
      number       = {4},
      issn         = {1744-4292},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2025-00429},
      pages        = {315-340},
      year         = {2025},
      note         = {2025 Apr;21(4):315-340},
      abstract     = {The circadian clock regulates key physiological processes,
                      including cellular responses to DNA damage. Circadian-based
                      therapeutic strategies optimize treatment timing to enhance
                      drug efficacy and minimize side effects, offering potential
                      for precision cancer treatment. However, applying these
                      strategies in cancer remains limited due to a lack of
                      understanding of the clock's function across cancer types
                      and incomplete insights into how the circadian clock affects
                      drug responses. To address this, we conducted deep circadian
                      phenotyping across a panel of breast cancer cell lines.
                      Observing diverse circadian dynamics, we characterized
                      metrics to assess circadian rhythm strength and stability in
                      vitro. This led to the identification of four distinct
                      circadian-based phenotypes among 14 breast cancer cell
                      models: functional, weak, unstable, and dysfunctional
                      clocks. Furthermore, we demonstrate that the circadian clock
                      plays a critical role in shaping pharmacological responses
                      to various anti-cancer drugs and we identify circadian
                      features descriptive of drug sensitivity. Collectively, our
                      findings establish a foundation for implementing
                      circadian-based treatment strategies in breast cancer,
                      leveraging clock phenotypes and drug sensitivity patterns to
                      optimize therapeutic outcomes.},
      keywords     = {Breast Cancer (Other) / Circadian Clock (Other) / Circadian
                      Medicine (Other) / Systems Biology (Other)},
      cin          = {BE01},
      ddc          = {570},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39994450},
      doi          = {10.1038/s44320-025-00092-7},
      url          = {https://inrepo02.dkfz.de/record/299469},
}