TY  - JOUR
AU  - Divé, Iris
AU  - Hahnefeld, Lisa
AU  - Wenger, Katharina J
AU  - Kögel, Donat
AU  - Steinbach, Joachim
AU  - Geisslinger, Gerd
AU  - Ronellenfitsch, Michael W
AU  - Tegeder, Irmgard
TI  - Plasma lipidomic and metabolomic profiles in high-grade glioma patients before and after 72-h presurgery water-only fasting.
JO  - Molecular oncology
VL  - 19
IS  - 8
SN  - 1574-7891
CY  - Hoboken, NJ
PB  - John Wiley & Sons, Inc.
M1  - DKFZ-2025-00434
SP  - 2249-2269
PY  - 2025
N1  - 2025 Aug;19(8):2249-2269
AB  - Glioblastoma (GB) is the most aggressive primary brain tumor with poor prognosis despite multimodal therapy. Calorie-restricted diets have emerged as putative strategies to augment anticancer therapies. We employed UHPLC-high-resolution mass spectrometry analyses of plasma lipids and polar metabolites to assess the systemic metabolic effects of a 72-h preoperative fasting period in IDH-wild-type glioma patients (n = 9 GB and n = 1 diffuse pediatric-type high-grade H3/IDH-wildtype) who participated in the prospective ERGO3 trial (NCT04461938). Fasting reduced lysophosphatidylcholines (LPC, LPC-O), lysophosphatidylethanolamines (LPE, LPE-O), and increased free fatty acids and carnitines. Triglyceride (TG) profiles shifted from short-chain TGs (42-48 C-atoms) to very long-chain TGs (58-60 C-atoms) indicating an exploitation of neutral lipid stores. Branched-chain amino acids, aminobutyric acid, and uric acids were increased, and glucose reduced after fasting. The effects of fasting were comparable in men and women. To our knowledge, this is the first study that evaluated the effects of fasting on systemic lipid/metabolite levels in GB patients. Our results may hold promise for integrating fasting interventions as a component of a potential metabolic tumor therapy.
KW  - fasting (Other)
KW  - glioblastoma (Other)
KW  - lipidomic (Other)
KW  - lysophosphatidylcholines (Other)
KW  - metabolomic (Other)
KW  - plasma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39992790
DO  - DOI:DOI:10.1002/1878-0261.70003
UR  - https://inrepo02.dkfz.de/record/299474
ER  -