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@ARTICLE{Div:299474,
      author       = {I. Divé$^*$ and L. Hahnefeld and K. J. Wenger$^*$ and D.
                      Kögel and J. Steinbach$^*$ and G. Geisslinger and M. W.
                      Ronellenfitsch$^*$ and I. Tegeder},
      title        = {{P}lasma lipidomic and metabolomic profiles in high-grade
                      glioma patients before and after 72-h presurgery water-only
                      fasting.},
      journal      = {Molecular oncology},
      volume       = {19},
      number       = {8},
      issn         = {1574-7891},
      address      = {Hoboken, NJ},
      publisher    = {John Wiley $\&$ Sons, Inc.},
      reportid     = {DKFZ-2025-00434},
      pages        = {2249-2269},
      year         = {2025},
      note         = {2025 Aug;19(8):2249-2269},
      abstract     = {Glioblastoma (GB) is the most aggressive primary brain
                      tumor with poor prognosis despite multimodal therapy.
                      Calorie-restricted diets have emerged as putative strategies
                      to augment anticancer therapies. We employed
                      UHPLC-high-resolution mass spectrometry analyses of plasma
                      lipids and polar metabolites to assess the systemic
                      metabolic effects of a 72-h preoperative fasting period in
                      IDH-wild-type glioma patients (n = 9 GB and n = 1 diffuse
                      pediatric-type high-grade H3/IDH-wildtype) who participated
                      in the prospective ERGO3 trial (NCT04461938). Fasting
                      reduced lysophosphatidylcholines (LPC, LPC-O),
                      lysophosphatidylethanolamines (LPE, LPE-O), and increased
                      free fatty acids and carnitines. Triglyceride (TG) profiles
                      shifted from short-chain TGs (42-48 C-atoms) to very
                      long-chain TGs (58-60 C-atoms) indicating an exploitation of
                      neutral lipid stores. Branched-chain amino acids,
                      aminobutyric acid, and uric acids were increased, and
                      glucose reduced after fasting. The effects of fasting were
                      comparable in men and women. To our knowledge, this is the
                      first study that evaluated the effects of fasting on
                      systemic lipid/metabolite levels in GB patients. Our results
                      may hold promise for integrating fasting interventions as a
                      component of a potential metabolic tumor therapy.},
      keywords     = {fasting (Other) / glioblastoma (Other) / lipidomic (Other)
                      / lysophosphatidylcholines (Other) / metabolomic (Other) /
                      plasma (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39992790},
      doi          = {DOI:10.1002/1878-0261.70003},
      url          = {https://inrepo02.dkfz.de/record/299474},
}