% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Minges:299478,
      author       = {P. Minges$^*$ and M. Eder$^*$ and A.-C. Eder$^*$},
      title        = {{D}ual-{L}abeled {S}mall {P}eptides in {C}ancer {I}maging
                      and {F}luorescence-{G}uided {S}urgery: {P}rogress and
                      {F}uture {P}erspectives.},
      journal      = {Pharmaceuticals},
      volume       = {18},
      number       = {2},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2025-00438},
      pages        = {143},
      year         = {2025},
      abstract     = {Dual-labeled compounds that combine radiolabeling and
                      fluorescence labeling represent a significant advancement in
                      precision oncology. Their clinical implementation enhances
                      patient care and outcomes by leveraging the high sensitivity
                      of radioimaging for tumor detection and taking advantage of
                      fluorescence-based optical visualization for surgical
                      guidance. Non-invasive radioimaging facilitates immediate
                      identification of both primary tumors and metastases, while
                      fluorescence imaging assists in decision-making during
                      surgery by offering a spatial distinction between malignant
                      and non-malignant tissue. These advancements hold promise
                      for enhancing patient outcomes and personalization of cancer
                      treatment. The development of dual-labeled molecular probes
                      targeting various cancer biomarkers is crucial in addressing
                      the heterogeneity inherent in cancer pathology and recent
                      studies had already demonstrated the impact of dual-labeled
                      compounds in surgical decision-making (NCT03699332,
                      NCT03407781). This review focuses on the development and
                      application of small dual-labeled peptides in the imaging
                      and treatment of various cancer types. It summarizes the
                      biomarkers targeted to date, tracing their development from
                      initial discovery to the latest advancements in
                      peptidomimetics. Through comprehensive analysis of recent
                      preclinical and clinical studies, the review demonstrates
                      the potential of these dual-labeled peptides to improve
                      tumor detection, localization, and resection. Additionally,
                      it highlights the evolving landscape of dual-modality
                      imaging, emphasizing its critical role in advancing
                      personalized and effective cancer therapy. This synthesis of
                      current research underscores the promise of dual-labeled
                      peptides in enhancing diagnostic accuracy and therapeutic
                      outcomes in oncology.},
      subtyp        = {Review Article},
      keywords     = {dual imaging (Other) / dual labeling (Other) /
                      dual-modality imaging (Other) / fluorescence labeling
                      (Other) / fluorescence-guided surgery (Other) / hybrid
                      molecule (Other) / isotope labeling (Other) /
                      peptidomimetics (Other) / small molecules (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40005958},
      doi          = {10.3390/ph18020143},
      url          = {https://inrepo02.dkfz.de/record/299478},
}