TY  - JOUR
AU  - Tranter, Eva
AU  - Busch, David
AU  - Heck, Clarissa
AU  - Blau, Igor Wolfgang
AU  - Nogai, Axel
AU  - Schiele, Phillip
AU  - Meisel, Christian
AU  - Bullinger, Lars
AU  - Frentsch, Marco
AU  - Na, Il-Kang
TI  - Advanced disease and CD8+ TEMRA cells predict severe infections in multiple myeloma.
JO  - Frontiers in immunology
VL  - 16
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2025-00449
SP  - 1532645
PY  - 2025
AB  - Infections are a major cause of early morbidity and mortality in patients with multiple myeloma (MM) who are characterized by immunodeficiency secondary to disease. However, prospectively collected data on infection risk in this population are scarce. We aimed at identifying parameters in monoclonal gammopathy of undetermined significance (MGUS) and newly diagnosed MM (NDMM) patients with predictive power for early severe infections (SI).We conducted a prospective study with newly diagnosed MGUS and NDMM patients. Besides clinical and laboratory data, immune parameters were collected at initial diagnosis before therapy initiation. Primary endpoint was the occurrence of SI within 12 months after diagnosis.45
KW  - Humans
KW  - Multiple Myeloma: immunology
KW  - Male
KW  - Female
KW  - Aged
KW  - Middle Aged
KW  - CD8-Positive T-Lymphocytes: immunology
KW  - Prospective Studies
KW  - Infections: immunology
KW  - Infections: etiology
KW  - Monoclonal Gammopathy of Undetermined Significance: immunology
KW  - Monoclonal Gammopathy of Undetermined Significance: diagnosis
KW  - Risk Factors
KW  - Aged, 80 and over
KW  - Prognosis
KW  - MGUS (Other)
KW  - Multiple Myeloma (Other)
KW  - infection (Other)
KW  - risk score (Other)
KW  - secondary immunodeficiency (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40013147
C2  - pmc:PMC11862831
DO  - DOI:10.3389/fimmu.2025.1532645
UR  - https://inrepo02.dkfz.de/record/299489
ER  -