%0 Journal Article
%A Licher, Jörg
%A Achenbach, Julia
%A Köhn, Janett
%A Diefenhardt, Markus
%A Fleischmann, Maximilian
%A Rödel, Claus
%A Tselis, Nikolaos
%A Ramm, Ulla
%A Scherf, Christian
%T Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer.
%J Strahlentherapie und Onkologie
%V 201
%N 9
%@ 0179-7158
%C Heidelberg
%I Springer Medizin
%M DKFZ-2025-00452
%P 940-952
%D 2025
%Z 2025 Sep;201(9):940-952
%X Facial skin cancer of 42 elderly frail patients was treated with individualised 3D-printed mould applicators for high-dose-rate (HDR) brachytherapy. The dosimetric outcome was compared to conventionally manufactured individual moulds used before.Tumour-adapted HDR brachytherapy source paths were pre-planned and dosimetrically optimised in the brachytherapy treatment planning system (TPS) using computed tomography (CT) data and considered in the design of the patient-individual moulds. Dosimetric outcome for the planning target volumes and organs at risk were statistically evaluated and compared for pre-planning, final clinical treatment planning with TG-43 formalism and retrospective tissue, material and CT density related TG-186 calculations.Pre-planning allows reliable brachytherapy source paths design to achieve intended dosimetric clinical goals. The 3D-printed patient-specific moulds show a clear advantage in the dosimetric coverage of the target volume (improving D90 from 98.3
%K 3D printing (Other)
%K Brachytherapy (Other)
%K Individual moulds (Other)
%K Radiotherapy (Other)
%K Skin cancer (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40009080
%R 10.1007/s00066-025-02372-5
%U https://inrepo02.dkfz.de/record/299492